# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4628822 | Binding | Protac activity at CRBN/CDK6 in human Jurkat cells assessed as formation of binary and ternary complex resulting in putative Hook effect measured after 24 hrs by capillary electrophoresis | Homo sapiens | 1 | ALA4627338 | cell-based format | Scientific Literature | |
2. | ALA4628823 | Binding | Protac activity at CRBN/CDK4 in human Jurkat cells assessed as formation of binary and ternary complex resulting in putative Hook effect measured after 24 hrs by capillary electrophoresis | Homo sapiens | 1 | ALA4627338 | cell-based format | Scientific Literature | |
3. | ALA4628824 | Binding | Inhibition of human CDK4/cyclin-D1 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | ALA4627338 | protein complex format | Scientific Literature | |
4. | ALA4628825 | Binding | Inhibition of human CDK6/cyclin-D3 using RB protein as substrate by [gamma-33P]-ATP assay | Homo sapiens | 10 | ALA4627338 | protein complex format | Scientific Literature | |
5. | ALA4628828 | Binding | Protac activity at CRBN/CDK4 in human Jurkat cells assessed as induction of CDK4 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | ALA4627338 | cell-based format | Scientific Literature | |
6. | ALA4628829 | Binding | Protac activity at CRBN/CDK6 in human Jurkat cells assessed as induction of CDK6 degradation measured after 24 hrs by capillary electrophoresis | Homo sapiens | 4 | ALA4627338 | cell-based format | Scientific Literature | |
7. | ALA4628834 | Binding | Protac activity at CRBN/CDK4 in human epoxomicin pretreated Jurkat cells assessed as decrease in CDK4 protein level measured after 5 hrs | Homo sapiens | 1 | ALA4627338 | cell-based format | Scientific Literature | |
8. | ALA4628837 | Binding | Protac activity at CRBN/CDK6 in human epoxomicin pretreated Jurkat cells assessed as decrease in CDK6 protein level measured after 5 hrs | Homo sapiens | 1 | ALA4627338 | cell-based format | Scientific Literature | |
9. | ALA5104674 | Binding | PROTAC activity at CRBN/CDK4 in human MOLT-4 cells assessed as induction of CDK4 degradation incubated for 5 hrs by mass spectrometry based proteomic analysis | Homo sapiens | 1 | ALA5104095 | cell-based format | Scientific Literature | |
10. | ALA5104675 | Binding | PROTAC activity at CRBN/CDK6 in human MOLT-4 cells assessed as induction of CDK6 degradation incubated for 5 hrs by mass spectrometry based proteomic analysis | Homo sapiens | 1 | ALA5104095 | cell-based format | Scientific Literature |