# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4622293 | B | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 7.4 by flow cytomtery based competitive fluorescence assay | Homo sapiens | 29 | ALA4619807 | cell-based format | Scientific Literature | |
2. | ALA4622294 | B | Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins by flow cytomtery based competitive fluorescence assay | Mus musculus | 13 | ALA4619807 | cell-based format | Scientific Literature | |
3. | ALA4622295 | B | Selectivity index, ratio of IC50 for inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells to IC50 for inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK292 cells | Homo sapiens | 8 | ALA4619807 | cell-based format | Scientific Literature | |
4. | ALA4622300 | B | Binding affinity to sigma 2 receptor (unknown origin) | Homo sapiens | 7 | ALA4619807 | assay format | Scientific Literature | |
5. | ALA4622312 | P | Aqueous solubility at pH 7.4 by pION method | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4622313 | P | Aqueous solubility at pH 4 by pION method | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4622314 | P | Lipophilicity, change in Constant K of the compound by RP-HPLC analysis relative to PPTN | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4622315 | A | Bioavailability in rat at 1 to 10 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
9. | ALA4622316 | A | Cmax in rat at 10 mg/kg, ip after 3 to 4 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
10. | ALA4622317 | A | Tmax in rat at 10 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
11. | ALA4622318 | A | Drug level in rat at 10 mg/kg, ip after 12 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
12. | ALA4622319 | A | Plasma concentration in rat at 1 mg/kg, ip after 2 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
13. | ALA4622320 | A | Plasma concentration in rat at 1 mg/kg, ip after 4 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
14. | ALA4622321 | A | Half life in rat at 1 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
15. | ALA4622322 | A | Permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 2 | ALA4619807 | cell-based format | Scientific Literature | |
16. | ALA4622323 | T | Toxicity in human HepG2 cells | Homo sapiens | 2 | ALA4619807 | cell-based format | Scientific Literature | |
17. | ALA4622330 | P | Stability in simulated intestinal fluid assessed as compound remaining level at 120 mins | 2 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4622331 | P | Stability in simulated gastric fluid assessed as compound remaining level at 120 mins | 2 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4622332 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA4619807 | single protein format | Scientific Literature | |
20. | ALA4622333 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4619807 | single protein format | Scientific Literature |