# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4624179 | Functional | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as increase in cytosolic calcium level at 1 mM by Fluo-2-AM dye based fluorescence assay | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
2. | ALA4624181 | Functional | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as increase in cytosolic calcium level at 1 mM in presence of 1 mM TAS2R46 antagonist 3HDC by Fluo-2-AM dye based fluorescence assay | Homo sapiens | 2 | ALA4622880 | cell-based format | Scientific Literature | |
3. | ALA4624182 | ADME | Effect on basal superoxide anion production in human BEAS2B cells expressing human TAS2R46 at 1 uM after 1 hr by cytochrome C reduction assay | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
4. | ALA4624184 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced superoxide anion generation at 1 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins by cytochrome C reduction assay | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
5. | ALA4624186 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antioxidant activity by measuring reduction in PMA-induced superoxide anion generation at 1 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins in presence of 1 uM TAS2R46 antagonist 3HDC by cytochrome C reduction assay | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
6. | ALA4624188 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced iNOS protein level at 1 uM incubated for 18 hrs by TRITC-phalloidin/DAPI staining based analysis | Homo sapiens | 3 | ALA4622880 | cell-based format | Scientific Literature | |
7. | ALA4624190 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced iNOS mRNA level at 1 uM incubated for 18 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4622880 | cell-based format | Scientific Literature | |
8. | ALA4624191 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced MUC5AC expression at 1 uM incubated for 18 hrs by TRITC-phalloidin/DAPI staining based analysis | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
9. | ALA4624193 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
10. | ALA4624195 | Binding | Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 1 uM incubated for 18 hrs in presence of 1 uM TAS2R46 antagonist 3HDC by qRT-PCR analysis | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
11. | ALA4624197 | Binding | Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-4 gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
12. | ALA4624199 | Binding | Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-10 gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4622880 | cell-based format | Scientific Literature | |
13. | ALA4624201 | Binding | Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-4 gene expression at 1 uM incubated for 18 hrs in presence of 1 uM TAS2R46 antagonist 3HDC by qRT-PCR analysis | Homo sapiens | 1 | ALA4622880 | cell-based format | Scientific Literature | |
14. | ALA4624202 | Binding | Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-10 gene expression at 1 uM incubated for 18 hrs in presence of 1 uM TAS2R46 antagonist 3HDC by qRT-PCR analysis | Homo sapiens | 1 | ALA4622880 | cell-based format | Scientific Literature |