#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4603688	B	Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method	Homo sapiens	13		cell-based format	Scientific Literature
2.	ALA4603689	B	Agonist activity at human TLR8 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method	Homo sapiens	12		cell-based format	Scientific Literature
3.	ALA4603690	B	Agonist activity at TLR7/8 in dog PBMC assessed as TNFalpha secretion at 20 uM after 29 hrs by ELISA (Rvb = 8 +/- 2 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
4.	ALA4603691	B	Agonist activity at TLR7/8 in dog PBMC assessed as IL-12 secretion at 20 uM after 29 hrs by ELISA (Rvb = 18 +/- 8 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
5.	ALA4603692	B	Agonist activity at TLR7/8 in dog PBMC assessed as IL-6 secretion at 20 uM after 29 hrs by ELISA (Rvb = 310 +/- 90 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
6.	ALA4603693	B	Agonist activity at TLR7/8 in dog PBMC assessed as IL-10 secretion at 20 uM after 29 hrs by ELISA (Rvb = 33 +/- 16 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
7.	ALA4603694	B	Agonist activity at TLR7/8 in dog PBMC assessed as IL-2 secretion at 20 uM after 29 hrs by ELISA (Rvb = 47 +/- 20 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
8.	ALA4603695	B	Agonist activity at TLR7/8 in dog PBMC assessed as IFNgamma secretion at 20 uM after 29 hrs by ELISA (Rvb = 0.4 +/- 0.7 pg/ml)	Canis lupus familiaris	13		cell-based format	Scientific Literature
9.	ALA4603696	B	Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method relative to resiquimod	Homo sapiens	3		cell-based format	Scientific Literature
10.	ALA4603697	B	Agonist activity at human TLR8 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method relative to resiquimod	Homo sapiens	3		cell-based format	Scientific Literature
11.	ALA4603698	B	Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method relative to imiquimod	Homo sapiens	3		cell-based format	Scientific Literature
12.	ALA4603699	B	Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in TNFalpha secretion at 20 uM after 30 to 48 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
13.	ALA4603700	B	Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in IL-12 secretion at 20 uM after 30 to 48 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
14.	ALA4603701	B	Agonist activity at TLR7/8 in dog PBMC assessed as maximal increase in IFN-gamma secretion at 20 uM after 30 to 48 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
15.	ALA4603702	B	Agonist activity at TLR7/8 in dog PBMC assessed as increase in TNFalpha secretion at 20 uM measured over 24 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
16.	ALA4603703	B	Agonist activity at TLR7/8 in dog PBMC assessed as increase in IL-12 secretion at 20 uM measured over 24 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
17.	ALA4603704	B	Agonist activity at TLR7/8 in dog PBMC assessed as increase in IFN-gamma secretion at 20 uM measured over 24 hrs by ELISA	Canis lupus familiaris	13		cell-based format	Scientific Literature
18.	ALA4603705	P	Solubility of the compound at >100 uM		13		small-molecule physicochemical format	Scientific Literature