| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4618780 | B | Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome as substrate preincubated for 10 mins followed by compound addition and measured after 1 hr in presence of ATP by LIPGLO luminescence based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA4618781 | B | Inhibition of full length C-terminal His6tagged TVMV-His-pFBgate fused human DGK-zeta expressed in baculovirus infected Sf9 insect cells using liposome as substrate preincubated for 10 mins followed by compound addition and measured after 1 hr in presence of ATP by LIPGLO luminescence based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4618782 | B | Inhibition of DGKA/DGKZ in human CD8 cells assessed as induction of CD8 activation by measuring IFNgamma level after 20 hrs by AlphaLISA assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA4618783 | B | Inhibition of DGKalpha/zeta in human whole blood assessed as induction of T-cell activation by measuring IFNgamma level preincubated for 1 hr followed by anti-human CD3/CD28 stimulation and measured after 24 hrs by AlphaLISA assay | Homo sapiens | 7 | tissue-based format | Scientific Literature |
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