# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4618799 | B | Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
2. | ALA4618800 | P | Thermodynamic solubility in 0.001N HCl by HPLC analysis | 18 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4618801 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
4. | ALA4618802 | B | Inhibition of NPC1/VDAC1 in HUVEC cells assessed as inhibition of tube formation at 3 uM measured after 24 hrs by Calcein-AM staining based fluorescence microscopy analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4618803 | B | Inhibition of NPC1 in HUVEC cells assessed as accumulation of cholesterol in perinuclear structure at 0.2 uM incubated for 24 hrs by filipin staining based confocal microscopy analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
6. | ALA4618804 | B | Activation of AMPK in HUVEC cells assessed as phosphorylation of acetyl CoA carboxylase measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4618805 | B | Inhibition of mTOR in HUVEC cells assessed as reduction in phosphorylation of p70S6K measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4618806 | B | Inhibition of VEGFR2 glycosylation in HUVEC cells assessed as disappearance of VEGFR2 at 0.5 to 2 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4618807 | F | Effect on VEGFR2 localization in human HUVEC cells assessed as accumulation of VEGFR2 in perinuclear region at 2 uM by DAPI staining based confocal micrscopy | Homo sapiens | 2 | cell-based format | Scientific Literature |