| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4630441 | Binding | Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay | Homo sapiens | 25 | ALA4627411 | cell-based format | Scientific Literature | |
| 2. | ALA4630442 | Functional | Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay | Homo sapiens | 31 | ALA4627411 | cell-based format | Scientific Literature | |
| 3. | ALA4630443 | ADME | Metabolic stability in rat hepatocytes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4627411 | cell-based format | Scientific Literature | |
| 4. | ALA4630444 | ADME | Metabolic stability in human hepatocytes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 5 | ALA4627411 | cell-based format | Scientific Literature | |
| 5. | ALA4630445 | ADME | Clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 5 | ALA4627411 | organism-based format | Scientific Literature | |
| 6. | ALA4630446 | ADME | Oral bioavailability in rat at 2 mg/kg | Rattus norvegicus | 5 | ALA4627411 | organism-based format | Scientific Literature |
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