# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4619454 | Binding | Protac activity at cereblon/IKZF1 in human SW480 cells assessed as induction of IKZF1 degradation at 5 to 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
2. | ALA4619456 | Binding | Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | Homo sapiens | 11 | ALA4616722 | single protein format | Scientific Literature | |
3. | ALA4619457 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation incubated for 24 hrs by Western blot assay | Homo sapiens | 9 | ALA4616722 | cell-based format | Scientific Literature | |
4. | ALA4619458 | Functional | Antiproliferative activity against human SW480 cells incubated for 72 hrs by CCK8 assay | Homo sapiens | 11 | ALA4616722 | cell-based format | Scientific Literature | |
5. | ALA4619459 | Functional | Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA4616722 | cell-based format | Scientific Literature | |
6. | ALA4619460 | ADME | Permeability in human Caco2 cells | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
7. | ALA4619461 | Binding | Protac activity at cereblon/PDE6D in human MIAPaCa2 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
8. | ALA4619462 | Functional | Antiproliferative activity against human MIAPaCa2 cells incubated for 72 hrs by CCK8 assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
9. | ALA4619463 | Binding | Protac activity at cereblon/PDE6D in human Panc1 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
10. | ALA4619464 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 2 | ALA4616722 | cell-based format | Scientific Literature | |
11. | ALA4619466 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs in presence of 30 uM deltazinone by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
12. | ALA4619467 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs in presence of 30 uM pomalidomide by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
13. | ALA4619468 | Functional | Antiproliferative activity against human SW480 cells incubated for 72 hrs in presence of 30 uM pomalidomide by CCK8 assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
14. | ALA4619469 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation at 10 uM incubated for 24 hrs in presence of 10 uM proteasome inhibitor MG-132 by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
15. | ALA4619470 | Binding | Protac activity at cereblon/IKZF3 in human SW480 cells assessed as induction of IKZF1 degradation at 5 to 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature | |
16. | ALA4619471 | Binding | Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in ERK phosphorylation at 5 to 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis | Homo sapiens | 2 | ALA4616722 | organism-based format | Scientific Literature | |
17. | ALA4619472 | Binding | Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in Akt phosphorylation at 5 to 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis | Homo sapiens | 1 | ALA4616722 | organism-based format | Scientific Literature | |
18. | ALA4619473 | Binding | Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in ERK phosphorylation at 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis | Homo sapiens | 1 | ALA4616722 | organism-based format | Scientific Literature | |
19. | ALA4619474 | Binding | Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in Akt phosphorylation at 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis | Homo sapiens | 1 | ALA4616722 | organism-based format | Scientific Literature | |
20. | ALA4619475 | Binding | Protac activity at cereblon/PDE6D in human SW480 cells assessed as induction of PDE6D degradation at 10 uM by immunostaining assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature |