| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4612758 | F | Antiproliferative activity against human HAP1 cells harboring CDK13 C1017S mutant measured after 72 hrs by Celltiter glo assay | Homo sapiens | 1 | ALA4610118 | cell-based format | Scientific Literature | |
| 2. | ALA4612759 | F | Antiproliferative activity against human HAP1 cells measured after 72 hrs by Celltiter glo assay | Homo sapiens | 1 | ALA4610118 | cell-based format | Scientific Literature | |
| 3. | ALA4612760 | F | Antiproliferative activity against human HAP1 cells harboring CDK12 C1039S mutant measured after 72 hrs by Celltiter glo assay | Homo sapiens | 1 | ALA4610118 | cell-based format | Scientific Literature | |
| 4. | ALA4612762 | B | Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled Ser/Thr 12 as substrate measured after 1 hr by Z'-lyte assay | Homo sapiens | 23 | ALA4610118 | cell-based format | Scientific Literature | |
| 5. | ALA4612763 | B | Inhibition of recombinant human full-length His-tagged CDK7/Cyclin H/MNAT1 expressed in baculovirus infection system using Cdk7/9tide as substrate measured after 1 hr by Alexa Fluor 647 ADP Tracer-based Adapta assay | Homo sapiens | 23 | ALA4610118 | assay format | Scientific Literature | |
| 6. | ALA4612764 | B | Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measured after 1 hr in presence of Alexa Fluor 647 ADP Tracer-based Adapta assay | Homo sapiens | 23 | ALA4610118 | assay format | Scientific Literature | |
| 7. | ALA4612765 | B | Inhibition of biotinylated-THZ1 binding to CDK12/CDK13 in human Jurkat cells assessed as reduction in cyclin K pull down by measuring residual protein level at 500 nM preincubated for 6 hrs followed by biotinylated-THZ1 addition and measured Western blotting based pulldown assay relative to control | Homo sapiens | 23 | ALA4610118 | cell-based format | Scientific Literature | |
| 8. | ALA4612766 | B | Binding affinity to CDK12 (unknown origin) assessed as change in molecular weight at 10 fold excess of protein measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 1 | ALA4610118 | single protein format | Scientific Literature | |
| 9. | ALA4612767 | B | Binding affinity to Cyclin K (unknown origin) assessed as change in molecular weight at 10 fold excess of protein measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 1 | ALA4610118 | single protein format | Scientific Literature | |
| 10. | ALA4612768 | B | Binding affinity to CDK12 (1025 to 1041 residues) (unknown origin) assessed as Cys1039-adduct formation at 10 fold excess of protein measured after 1 hr by by capillary electrophoresis-MS/MS analysis | Homo sapiens | 1 | ALA4610118 | single protein format | Scientific Literature | |
| 11. | ALA4612769 | B | Binding affinity to wild-type human partial length CDK13 (H675 to S1054 residues) expressed in mammalian expression system at 1 uM by Kinomescan method | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 12. | ALA4612770 | B | Inhibition of recombinant human full-length His-tagged CDK1/cyclin B expressed in baculovirus expression system using FRET-labeled Ser/Thr 18 as substrate measured after 1 hr by Z'-lyte assay | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 13. | ALA4612771 | B | Inhibition of kinase tracer 236 binding to recombinant human full-length N-terminal GST-tagged CDK3/cyclin E1 expressed in baculovirus expression system measured after 1 hr by LanthaScreen Eu Kinase Binding Assay | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 14. | ALA4612772 | B | Inhibition of recombinant human full-length GST-tagged CDK4/Cyclin D1 expressed in baculovirus infection system measured after 1 hr by Alexa Fluor 647 ADP Tracer-based Adapta assay | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 15. | ALA4612773 | B | Inhibition of recombinant human full-length GST/His-tagged CDK5/p25 expressed in baculovirus expression system using FRET-labeled Ser/Thr 12 as substrate measured after 1 hr by Z'-lyte assay | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 16. | ALA4612774 | B | Inhibition of CDK6 (unknown origin) by adapta assay | Homo sapiens | 1 | ALA4610118 | single protein format | Scientific Literature | |
| 17. | ALA4612775 | B | Inhibition of kinase tracer 236 binding to recombinant human full-length His-tagged CDK8/cyclin C expressed in baculovirus expression system measured after 1 hr by LanthaScreen Eu Kinase Binding Assay | Homo sapiens | 1 | ALA4610118 | assay format | Scientific Literature | |
| 18. | ALA4612776 | B | Inhibition of human CDK12/cyclin K using Pol2-CTD as substrate by [gamma-33P]ATP-based radioisotope filter binding assay | Homo sapiens | 1 | ALA4610118 | protein complex format | Scientific Literature | |
| 19. | ALA4612777 | B | Inhibition of human CDK13/cyclin K using Pol2-CTD as substrate by [gamma-33P]ATP-based radioisotope filter binding assay | Homo sapiens | 1 | ALA4610118 | protein complex format | Scientific Literature | |
| 20. | ALA4612778 | B | Inhibition of kinase tracer 236 binding to recombinant human N-terminal GST-tagged full-length CDK14/Cyclin Y (2 to end residues) expressed in baculovirus infected Sf9 insect cells measured after 1 hr by LanthaScreen Eu Kinase Binding Assay | Homo sapiens | 1 | ALA4610118 | cell-based format | Scientific Literature |
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