| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619036 | B | Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 2. | ALA4619037 | B | Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assay | Homo sapiens | 20 | protein complex format | Scientific Literature | ||
| 3. | ALA4619038 | B | Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assay | Homo sapiens | 20 | protein complex format | Scientific Literature | ||
| 4. | ALA4619039 | B | Inhibition of human full length p110gamma using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 5. | ALA4619040 | B | Selectivity index, ratio of IC50 for human full length p110alpha/p85alpha to IC50 for recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 6. | ALA4619041 | B | Selectivity index, ratio of IC50 for human p110delta catalytic subunit/p85alpha to IC50 for recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 7. | ALA4619042 | B | Selectivity index, ratio of IC50 for human full length p110gamma to IC50 for recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA4619043 | P | Dissociation constant, acidic pKa of compound | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4619044 | A | Inhibition of human CYP3A4 | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 10. | ALA4619045 | A | Clearance in human hepatocytes at 1 uM measured up to 250 mins by UHPLC-HRMS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4619046 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4619047 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4619048 | B | Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4619049 | B | Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4619050 | B | Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4619051 | B | Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4619052 | B | Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4619053 | A | Protein binding in Sprague-Dawley rat plasma at 1 mg/kg administered as iv infusion for 30 mins and measured after 24 hrs by ESI-LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA4619054 | A | Clearance in Sprague-Dawley rat at 1 mg/kg administered as iv infusion for 30 mins and measured after 24 hrs by ESI-LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA4619055 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg administered as iv infusion for 30 mins and measured after 24 hrs by ESI-LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature |
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