| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4620800 | F | Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA4620801 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM in presence of NADPH generating system measured after 20 mins by LC-MS/MS analysis | Rattus norvegicus | 12 | microsome format | Scientific Literature | ||
| 3. | ALA4620802 | P | Solubility of the compound in JP1 fluid at pH 1.2 | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4620803 | P | Solubility of the compound in JP2 buffer at pH 6.8 | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4620804 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4620805 | A | Inhibition of CYP2C8 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4620806 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4620807 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4620808 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4620809 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4620810 | P | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4620811 | A | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4620812 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4620813 | A | Elimination half life in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4620814 | A | AUClast in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4620815 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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