# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4628607 | Functional | Antiproliferative activity against human NCI-N87 cells overexpressing HER2 assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
2. | ALA4628608 | Functional | Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
3. | ALA4628609 | Functional | Antiproliferative activity against human A431 cells overexpressing EGFR assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
4. | ALA4628610 | Functional | Antiproliferative activity against human BT474 cells overexpressing HER2 assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
5. | ALA4628611 | Functional | Antiproliferative activity against human Calu3 cells overexpressing HER2 assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
6. | ALA4628612 | Binding | Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation and measured after 6 mins by ELISA | Homo sapiens | 20 | ALA4627322 | cell-based format | Scientific Literature | |
7. | ALA4628613 | Binding | Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 7 | ALA4627322 | single protein format | Scientific Literature | |
8. | ALA4628614 | Binding | Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 7 | ALA4627322 | single protein format | Scientific Literature | |
9. | ALA4628627 | Functional | Potency index, ratio of lapatinib IC50 to test compound IC50 for antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4627322 | cell-based format | Scientific Literature | |
10. | ALA4628628 | Functional | Potency index, ratio of gefitinib IC50 to test compound IC50 for antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4627322 | cell-based format | Scientific Literature | |
11. | ALA4628629 | Functional | Potency index, ratio of erlotinib IC50 to test compound IC50 for antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4627322 | cell-based format | Scientific Literature | |
12. | ALA4628630 | Binding | Potency index, ratio of lapatinib IC50 to test compound IC50 for inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 3 | ALA4627322 | single protein format | Scientific Literature | |
13. | ALA4628631 | Binding | Potency index, ratio of gefitinib IC50 to test compound IC50 for inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 2 | ALA4627322 | single protein format | Scientific Literature | |
14. | ALA4628632 | Binding | Potency index, ratio of erlotinib IC50 to test compound IC50 for inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 2 | ALA4627322 | single protein format | Scientific Literature | |
15. | ALA4628633 | Binding | Potency index, ratio of lapatinib IC50 to test compound IC50 for inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 mins in presence of ATP by caliper mobility shift assay | Homo sapiens | 2 | ALA4627322 | single protein format | Scientific Literature |