| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4650107 | B | Thermal Shift Assay. Domain start/stop: M626-G740 | Homo sapiens | 1,014 | single protein format | EUbOPEN Chemogenomic Library | ||
| 2. | ALA4725212 | T | Incucyte cell viability with HEK293T | Homo sapiens | 1,713 | cell-based format | EUbOPEN Chemogenomic Library | ||
| 3. | ALA4725213 | T | Incucyte cell viability with human fibroblast | Homo sapiens | 1,718 | cell-based format | EUbOPEN Chemogenomic Library | ||
| 4. | ALA4725214 | T | Incucyte cell viability with U2OS | Homo sapiens | 1,712 | cell-based format | EUbOPEN Chemogenomic Library | ||
| 5. | ALA4727027 | B | Selectivity index, difference between pKd for full length BRDT BD1 in human HuT78 cell lysates to pKd for full length BRDT BD2 in human HuT78 cell lysates | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4727028 | B | Binding affinity to full length BRD2 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoproteomic binding assay | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 7. | ALA4727029 | B | Binding affinity to full length BRD3 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoproteomic binding assay | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 8. | ALA4727030 | F | Inhibition of LPS-induced MCP1 production in PBMC (unknown origin) | Not specified | 2 | tissue-based format | Scientific Literature | ||
| 9. | ALA4727031 | B | Selectivity index, difference between pKd for human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system to pKd for human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4727032 | B | Selectivity index, difference between pKd for human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system to pKd for human partial length TAF1L bromodomain 2 (Q1523 to D1654 residues) expressed in bacterial expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4727033 | B | Selectivity index, difference between pKd for human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system to pKd for human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4727034 | B | Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4727035 | B | Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4727036 | B | Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4727038 | F | Inhibition of LPS-induced IL6 production in human whole blood preincubated for 30 mins followed by LPS addition and measured after overnight incubation by mesoscale assay | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 16. | ALA4727039 | F | Inhibition of LPS-induced TNFalpha production in human whole blood preincubated for 30 mins followed by LPS addition and measured after overnight incubation by mesoscale assay | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA4727043 | P | Lipophilicity, logD of the compound at pH 7.4 by chromatographic method | 35 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA4727044 | B | Displacement of Alexa Fluor 647 labelled ligand from His6-thr-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 35 | single protein format | Scientific Literature | ||
| 19. | ALA4727045 | B | Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant (unknown origin) after 30 mins by TR-FRET assay | Homo sapiens | 35 | single protein format | Scientific Literature | ||
| 20. | ALA4727048 | B | Selectivity index, difference between pIC50 for His6-thr-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant (unknown origin) to pIC50 for His6-tagged BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant (unknown origin) | Homo sapiens | 34 | assay format | Scientific Literature |
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