# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4629018 | A | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM measured after 24 hrs by MTT assay relative to control | Mus musculus | 12 | ALA4627345 | cell-based format | Scientific Literature | |
2. | ALA4629019 | B | Inhibition of bovine COX1 at 100 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by ADPH-based fluorescence assay relative to control | Bos taurus | 14 | ALA4627345 | single protein format | Scientific Literature | |
3. | ALA4629020 | B | Inhibition of human recombinant COX-2 at 100 uM using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after 5 mins by ADPH-based fluorescence assay relative to control | Homo sapiens | 14 | ALA4627345 | single protein format | Scientific Literature | |
4. | ALA4629021 | B | Selectivity index, ratio of inhibition of human recombinant COX-2 at 100 uM to inhibition of bovine COX-1 at 100 uM | 14 | ALA4627345 | assay format | Scientific Literature | ||
5. | ALA4629024 | B | Inhibition of iNOS in mouse macrophages assessed as reduction in LPS-induced nitric oxide production at 50 uM incubated for overnight by griess assay relative to control | Mus musculus | 14 | ALA4627345 | single protein format | Scientific Literature | |
6. | ALA4629025 | B | Inhibition of iNOS in mouse macrophages assessed as reduction in LPS-induced nitric oxide production at 100 uM incubated for overnight by griess assay relative to control | Mus musculus | 14 | ALA4627345 | single protein format | Scientific Literature | |
7. | ALA4629026 | F | Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema formation at 100 mg/kg, po administered 1 hr before carrageenan stimulation and measured after up to 6 hrs relative to control | Rattus norvegicus | 14 | ALA4627345 | organism-based format | Scientific Literature |