# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4623818 | A | Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | Homo sapiens | 19 | ALA4622872 | cell-based format | Scientific Literature | |
2. | ALA4623819 | A | Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | Homo sapiens | 19 | ALA4622872 | cell-based format | Scientific Literature | |
3. | ALA4623820 | B | Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | Homo sapiens | 20 | ALA4622872 | cell-based format | Scientific Literature | |
4. | ALA4623821 | B | Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | Mus musculus | 19 | ALA4622872 | cell-based format | Scientific Literature | |
5. | ALA4623822 | B | Inhibition of human ERG by Ionworks high-throughput electrophysiology method | Homo sapiens | 16 | ALA4622872 | single protein format | Scientific Literature | |
6. | ALA4623823 | P | Distribution coefficient, log D of the compound in 1-octanol and PBS buffer at pH 7.4 measured after 30 mins by LC-MS analysis | 16 | ALA4622872 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4623824 | A | Apparent permeability of the compound at 5 uM measured after 4 hrs at pH 7.4 by PAMPA | 16 | ALA4622872 | assay format | Scientific Literature | ||
8. | ALA4623825 | P | Aqueous thermodynamic solubility of the compound at pH 6.8 measured after 4 hrs by UV-HPLC analysis | 16 | ALA4622872 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4623826 | A | Stability of the compound in mouse liver microsomes assessed as parent compound remaining measured after 0.5 hrs | Mus musculus | 16 | ALA4622872 | microsome format | Scientific Literature | |
10. | ALA4623827 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 16 | ALA4622872 | single protein format | Scientific Literature | |
11. | ALA4623828 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 16 | ALA4622872 | single protein format | Scientific Literature |