# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4621227 | B | Inhibition of Pseudomonas aeruginosa PA14 LasB using 2-Aminobenzoyl-AlaGly-Leu-Ala-4-Nitrobenzylamide as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET assay | Pseudomonas aeruginosa PA14 | 32 | single protein format | Scientific Literature | ||
2. | ALA4621234 | A | Inhibition of recombinant human MMP1 catalytic domain (106 to 261 residues) expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
3. | ALA4621235 | A | Inhibition of recombinant human His-tagged MMP2 expressed in CHO cells at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4621236 | A | Inhibition of recombinant human His-tagged MMP3 catalytic domain (Pro19 to Glu271 residues) expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
5. | ALA4621237 | A | Inhibition of recombinant human MMP7 expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
6. | ALA4621238 | A | Inhibition of recombinant human full-length MMP8 at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA4621239 | A | Inhibition of recombinant human His-tagged MMP14 expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
8. | ALA4621240 | A | Inhibition of recombinant human HDAC3 expressed in insect cells using R-H-K-K(Ac)-AFC as substrate by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4621241 | A | Inhibition of recombinant human HDAC8 expressed in baculovirus infected insect cells using R-H-K(Ac)-K(Ac)-AFC as substrate by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4621242 | A | Inhibition of recombinant human TACE1 expressed in insect cells using FRET-tagged substrate by FRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4621243 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA4621244 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
13. | ALA4621245 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA4621248 | A | Toxicity in Pseudomonas aeruginosa PA14 assessed as reduction in bacterial growth after 18 hrs | Pseudomonas aeruginosa | 5 | organism-based format | Scientific Literature | ||
15. | ALA4621249 | A | Toxicity in Clostridium histolyticum DSM 1126 assessed as reduction in bacterial growth after 48 hrs | Hathewaya histolytica | 5 | organism-based format | Scientific Literature |