| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4622293 | B | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 7.4 by flow cytomtery based competitive fluorescence assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 2. | ALA4622294 | B | Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins by flow cytomtery based competitive fluorescence assay | Mus musculus | 13 | cell-based format | Scientific Literature | ||
| 3. | ALA4622296 | B | Selectivity index, ratio of IC50 for inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK292 cells to iC50 for inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells | 2 | cell-based format | Scientific Literature | |||
| 4. | ALA4622312 | P | Aqueous solubility at pH 7.4 by pION method | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4622313 | P | Aqueous solubility at pH 4 by pION method | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4622314 | P | Lipophilicity, change in Constant K of the compound by RP-HPLC analysis relative to PPTN | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA4622324 | A | Unbound fraction in human plasma | Homo sapiens | 4 | cell-free format | Scientific Literature | ||
| 8. | ALA4622325 | A | Unbound fraction in mouse plasma | Mus musculus | 4 | cell-free format | Scientific Literature | ||
| 9. | ALA4622326 | A | Unbound fraction in rat plasma | Rattus norvegicus | 4 | cell-free format | Scientific Literature | ||
| 10. | ALA4622327 | F | Antiasthmatic activity in Aspergillus oryzae protease-mediated C57BL/6J mouse model of allergic asthma assessed as reduction in eosinophil infiltration in bronchoalveolar lavage fluid at 10 mg/kg, ip dosed 30 mins before OVA aerosol challenge and measured 2 days post-challenge by cell differential count assay | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 11. | ALA4622328 | F | Antinociceptive activity in Hsd:ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as reversal of mechano-allodynia in ipsilateral and hind paws at 10 umol/kg, ip by Frey filaments based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4622329 | F | Antinociceptive activity in Hsd:ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as time for peak reversal of mechano-allodynia in ipsilateral and hind paws at 10 umol/kg, ip by Frey filaments based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4622348 | A | Effect on hind paw response contralateral to injury in Hsd:ICR mouse model of chronic constriction injury-induced neuropathic pain at 10 umol/kg, ip by Frey filaments based assay | Mus musculus | 1 | organism-based format | Scientific Literature |
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