#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4650107	Binding	Thermal Shift Assay. Domain start/stop: M626-G740	Homo sapiens	1,014	ALA4649998	single protein format	EUbOPEN Chemogenomic Library
2.	ALA4701888	Functional	Antiproliferative activity against human KYSE-520 cells	Homo sapiens	20	ALA4699491	cell-based format	Scientific Literature
3.	ALA4701889	Binding	Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY122 incubated for 30 mins by fluorescence based DIFMUP assay	Homo sapiens	29	ALA4699491	assay format	Scientific Literature
4.	ALA4701891	Binding	Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assay	Homo sapiens	20	ALA4699491	cell-based format	Scientific Literature
5.	ALA4701892	Toxicity	Toxicity in mouse 3T3 cells assessed as PIF by NRU phototoxicity test relative to control	Mus musculus	2	ALA4699491	cell-based format	Scientific Literature
6.	ALA4701893	Toxicity	Toxicity in mouse 3T3 cells under irradiation by NRU phototoxicity test	Mus musculus	3	ALA4699491	cell-based format	Scientific Literature
7.	ALA4701899	Physicochemical	Aqueous solubility of the compound at pH 6.8		18	ALA4699491	small-molecule physicochemical format	Scientific Literature
8.	ALA4701900	Physicochemical	Lipophilicity, logP of the compound		18	ALA4699491	small-molecule physicochemical format	Scientific Literature
9.	ALA4701901	Physicochemical	Distribution coefficient, logD of the compound		18	ALA4699491	small-molecule physicochemical format	Scientific Literature
10.	ALA4701902	Binding	Inhibition of human ERG by Q-patch assay	Homo sapiens	18	ALA4699491	single protein format	Scientific Literature
11.	ALA4701904	ADME	Inhibition of CYP3A4 (unknown origin)	Homo sapiens	1	ALA4699491	single protein format	Scientific Literature
12.	ALA4701905	ADME	Inhibition of CYP2D6 (unknown origin)	Homo sapiens	1	ALA4699491	single protein format	Scientific Literature
13.	ALA4701906	ADME	Inhibition of CYP2C9 (unknown origin)	Homo sapiens	1	ALA4699491	single protein format	Scientific Literature
14.	ALA4701907	Functional	Inhibition of SHP2 in mouse xenografted with human KYSE-520 cells assessed as reduction in cellular p-ERK levels at 2.5 to 20 mg/kg, po administered as single dose by MSD assay	Mus musculus	1	ALA4699491	organism-based format	Scientific Literature
15.	ALA4701908	Functional	Inhibition of SHP2 in mouse xenografted with human KYSE-520 cells assessed as reduction in cellular DUSP6 mRNA levels at 2.5 to 20 mg/kg, po administered as single dose by RT-PCR analysis	Mus musculus	1	ALA4699491	organism-based format	Scientific Literature
16.	ALA4701909	Toxicity	Toxicity in NU/NU mouse xenografted with human KYSE-520 cells assessed as induction of body weight loss eat 2.5 to 20 mg/kg, po BID for 2 weeks	Mus musculus	1	ALA4699491	organism-based format	Scientific Literature
17.	ALA4701910	Functional	Antitumor activity against human KYSE-520 cells xenografted in NU/NU mouse assessed as reduction in tumor volume at 2.5 to 20 mg/kg, po BID for 2 weeks	Homo sapiens	1	ALA4699491	organism-based format	Scientific Literature
18.	ALA4701911	Functional	Antitumor activity against human KYSE-520 cells xenografted in NU/NU mouse assessed as induction of tumor stasis at 10 to 20 mg/kg, po BID for 2 weeks	Homo sapiens	1	ALA4699491	organism-based format	Scientific Literature
19.	ALA4701912	ADME	Clearance in C57BL/6 mouse at 1 mg/kg, iv by LC-MS/MS analysis	Mus musculus	1	ALA4699491	organism-based format	Scientific Literature
20.	ALA4701913	ADME	Volume of distribution at steady state in C57BL/6 mouse at 1 mg/kg, iv by LC-MS/MS analysis	Mus musculus	1	ALA4699491	organism-based format	Scientific Literature