| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4708483 | B | Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincubated with enzyme for 15 mins followed by substrate addition by fluorescence based assay | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 2. | ALA4708484 | B | Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincubated with enzyme for 15 mins followed by substrate addition by fluorescence based assay | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 3. | ALA4708485 | B | Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated with enzyme for 15 mins followed by substrate addition by fluorescence based assay | Homo sapiens | 34 | single protein format | Scientific Literature | ||
| 4. | ALA4708486 | F | Cytotoxicity aganist human TF-1 cells harboring IDH2 mutant | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4708488 | B | Inhibition of human IDH2 R140Q mutant expressed in TF-1 cells assessed as inhibition of 2-HG production at 0.1 uM incubated for 48 hrs by LC-MS/MS analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 6. | ALA4708489 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 100 ug/ml measured after 15 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 7. | ALA4708490 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 100 ug/ml measured after 45 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 8. | ALA4708491 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 100 ug/ml measured after 90 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 9. | ALA4708492 | B | Inhibition of human IDH2 R140Q mutant expressed in TF-1 cells assessed as inhibition of 2-HG production at 10 uM incubated for 48 hrs by LC-MS/MS analysis | Homo sapiens | 22 | cell-based format | Scientific Literature |
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