| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4670740 | F | Antioxidant activity against LPS-induced injury in C57BL/6 mouse assessed as increase in GSH/GSSG ratio at 10 mg/kg, ip qd administered for 3 days prior to LPS stimulation and measured after 12 hrs | Mus musculus | 1 | ALA4665802 | organism-based format | Scientific Literature | |
| 2. | ALA4670741 | B | Inhibition of FITC-9mer Nrf2 peptide interaction with human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 cells incubated for 30 mins by fluorescence polarization assay | Homo sapiens | 102 | ALA4665802 | cell-based format | Scientific Literature | |
| 3. | ALA4670742 | B | Binding affinity to human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 3 | ALA4665802 | assay format | Scientific Literature | |
| 4. | ALA4670743 | B | Binding affinity to biotinylated human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 by biolayer interferometry | Homo sapiens | 1 | ALA4665802 | assay format | Scientific Literature | |
| 5. | ALA4670744 | B | Binding affinity to biotinylated human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 assessed as association rate constant by biolayer interferometry | Homo sapiens | 1 | ALA4665802 | assay format | Scientific Literature | |
| 6. | ALA4670745 | B | Binding affinity to biotinylated human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 assessed as dissociation rate constant by biolayer interferometry | Homo sapiens | 1 | ALA4665802 | assay format | Scientific Literature | |
| 7. | ALA4670746 | A | Metabolic stability in human liver microsome assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4665802 | microsome format | Scientific Literature | |
| 8. | ALA4670747 | A | Metabolic stability in human liver microsome assessed as half-life at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4665802 | microsome format | Scientific Literature | |
| 9. | ALA4670748 | A | Intrinsic clearance in human liver microsome at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4665802 | microsome format | Scientific Literature | |
| 10. | ALA4670749 | A | Permeability of the compound at pH 7.4 incubated for 4 hrs by PAMPA | 4 | ALA4665802 | assay format | Scientific Literature | ||
| 11. | ALA4670750 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM using 7-ethoxycoumarin as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4665802 | single protein format | Scientific Literature | |
| 12. | ALA4670751 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4665802 | single protein format | Scientific Literature | |
| 13. | ALA4670752 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM using omeprazole as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4665802 | single protein format | Scientific Literature | |
| 14. | ALA4670753 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM using promethazine as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4665802 | single protein format | Scientific Literature | |
| 15. | ALA4670754 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM using fluconazole as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4665802 | single protein format | Scientific Literature | |
| 16. | ALA4670755 | A | Cmax in rat at 5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4665802 | organism-based format | Scientific Literature | |
| 17. | ALA4670756 | A | AUC (0 to t) in rat at 5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4665802 | organism-based format | Scientific Literature | |
| 18. | ALA4670757 | A | AUC (0 to infinity) in rat at 5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4665802 | organism-based format | Scientific Literature | |
| 19. | ALA4670758 | A | Half-life in rat at 5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4665802 | organism-based format | Scientific Literature | |
| 20. | ALA4670759 | A | MRT (0 to infinity) in rat at 5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4665802 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!