| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4683510 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as increase in phosphorylation of FOX01 at Ser256 residue at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 2. | ALA4683511 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis at 20 uM incubated for 24 hrs by MTT assay relative to control | Rattus norvegicus | 51 | cell-based format | Scientific Literature | ||
| 3. | ALA4683512 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay | Rattus norvegicus | 37 | cell-based format | Scientific Literature | ||
| 4. | ALA4683513 | F | Potency index, ratio of vincamine EC50 to test compound EC50 for cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4683514 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells at 10 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4683516 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 20 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4683517 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 5 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4683518 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 10 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4683519 | B | Activation of AKT in STZ-induced rat INS-1 832/13 cells assessed as increase in Akt phosphorylation at 5 to 20 uM after 24 hrs by AlphaLISA assay | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 10. | ALA4683521 | B | Activation of AKT in STZ-induced rat INS-1 832/13 cells assessed as increase in Akt phosphorylation at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 11. | ALA4683523 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis at 20 uM incubated for 24 hrs in presence of wortmannin by MTT assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4683524 | B | Activation of AKT in STZ-induced rat INS-1 832/13 cells assessed as increase in Akt phosphorylation at 20 uM after 24 hrs in presence of wortmannin by Western blot analysis | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
| 13. | ALA4683525 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as increase in phosphorylation of GSK3beta at Ser9 residue at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 14. | ALA4683526 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as decrease in caspase 9 protein expression at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 15. | ALA4683527 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as decrease in caspase 3 protein expression at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 16. | ALA4683528 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as decrease in cleaved-caspase 3 protein expression at 5 to 20 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA4683529 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as decrease in Bim mRNA expression at 5 to 20 uM after 24 hrs by RT-PCR analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 18. | ALA4683530 | B | Activation of PI3K/Akt signalling pathway in STZ-induced rat INS-1 832/13 cells assessed as decrease in p21 mRNA expression at 5 to 20 uM after 24 hrs by RT-PCR analysis | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 19. | ALA4683531 | F | Cytoprotective activity against STZ-induced rat INS-1 832/13 cells assessed as increase in IRS2 protein expression at 5 to 20 uM after 24 hrs Western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4683532 | F | Cytoprotective activity against STZ-induced rat INS-1 832/13 cells assessed as increase in IRS2 mRNA expression at 5 to 20 uM after 24 hrs RT-PCR analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature |
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