# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4679422 | B | Inhibition of KMO (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
2. | ALA4679429 | A | Permeability of compound at pH 7.4 by PAMPA assay | 16 | assay format | Scientific Literature | |||
3. | ALA4679430 | A | Ratio of drug level in brain to plasma of mouse at 10 mg/kg, po after 1 hr | Mus musculus | 9 | organism-based format | Scientific Literature | ||
4. | ALA4679431 | A | Drug uptake in mouse brain at 10 mg/kg, po after 1 hr | Mus musculus | 9 | organism-based format | Scientific Literature | ||
5. | ALA4679432 | A | Plasma concentration in mouse at 10 mg/kg, po after 1 hr | Mus musculus | 9 | organism-based format | Scientific Literature | ||
6. | ALA4679434 | B | Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 6 | mitochondrion format | Scientific Literature | ||
7. | ALA4679436 | B | Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis | Mus musculus | 20 | mitochondrion format | Scientific Literature | ||
8. | ALA4836414 | A | Plasma concentration in cynomolgus monkey at 5 mg/kg, po measured after 2 hrs of administration | Macaca fascicularis | 2 | organism-based format | Scientific Literature | ||
9. | ALA4836415 | A | Drug uptake in cynomolgus monkey striatum at 5 mg/kg, po measured after 2 hrs of administration | Macaca fascicularis | 2 | organism-based format | Scientific Literature | ||
10. | ALA4836416 | A | Ratio of drug level in cynomolgus monkey striatum to plasma at 5 mg/kg, po measured after 2 hrs of administration | Macaca fascicularis | 2 | organism-based format | Scientific Literature |