# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4731851 | Functional | Antiparasitic activity against Toxoplasma gondii ME49 tachyzoites infected in human HFF-1 cells assessed as inhibition of parasitic growth preincubated for 48 hrs followed by [5,6-3H]uracil addition and measured after 24 hrs by liquid scintillation counting analysis | Toxoplasma gondii | 17 | ALA4725488 | organism-based format | Scientific Literature | |
2. | ALA4731852 | Functional | Antiparasitic activity against Toxoplasma gondii ME49 bradyzoite infected in human HFF-1 cells assessed as inhibition of parasitic growth preincubated for 48 hrs followed by [5,6-3H]uracil addition and measured after 24 hrs by liquid scintillation counting analysis | Toxoplasma gondii | 17 | ALA4725488 | organism-based format | Scientific Literature | |
3. | ALA4731853 | ADME | Cytotoxicity against HFF cells assessed as reduction in cell viability incubated for 72 hrs by Cell titer assay | Homo sapiens | 17 | ALA4725488 | cell-based format | Scientific Literature | |
4. | ALA4731854 | Toxicity | Selectivity index, ratio of CC50 for human HFF cells to EC50 for Toxoplasma gondii ME49 tachyzoites infected in human HFF cells | 17 | ALA4725488 | cell-based format | Scientific Literature | ||
5. | ALA4731855 | Physicochemical | Lipophilicity log D of compound at pH 7.4 | 5 | ALA4725488 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4731856 | Physicochemical | Kinetic aqueous solubility of the compound in pH 7.4 | 5 | ALA4725488 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4731857 | ADME | Stability in CD-1 mouse liver microsomes assessed as parent compound remaining measured after 60 mins by LC-MS method | Mus musculus | 5 | ALA4725488 | microsome format | Scientific Literature | |
8. | ALA4731858 | ADME | Stability in CD-1 mouse plasma assessed as parent compound remaining measured after 60 mins by LC-MS/MS method | Mus musculus | 5 | ALA4725488 | cell-free format | Scientific Literature | |
9. | ALA4731859 | ADME | Permeability of compound by PAMPA-BBB assay | 5 | ALA4725488 | assay format | Scientific Literature | ||
10. | ALA4731865 | Toxicity | Selectivity index, ratio of CC50 for human HFF cells to EC50 for Toxoplasma gondii ME49 bradyzoite infected in human HFF cells | 17 | ALA4725488 | cell-based format | Scientific Literature |