# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4689520 | Binding | Protac activity at VHL/AR in human LNCaP cells assessed as degradation of AR at 0.01 uM measured after 6 hrs by Western blot analysis relative to control | 6 | ALA4680362 | cell-based format | Scientific Literature | ||
2. | ALA4689521 | Binding | Protac activity at VHL/AR in human LNCaP cells assessed as degradation of AR at 0.1 uM measured after 6 hrs by Western blot analysis relative to control | 8 | ALA4680362 | cell-based format | Scientific Literature | ||
3. | ALA4689522 | Binding | Protac activity at VHL/AR in human LNCaP cells assessed as degradation of AR at 1 uM measured after 6 hrs by Western blot analysis relative to control | 10 | ALA4680362 | cell-based format | Scientific Literature | ||
4. | ALA5141003 | Binding | Protac activity at VHL/Androgen receptor in human LNCaP cells assessed as Androgen receptor degradation | Homo sapiens | 1 | ALA5137058 | cell-based format | Scientific Literature | |
5. | ALA5141004 | Binding | Protac activity at VHL/Androgen receptor in human VCaP cells assessed as Androgen receptor degradation | Homo sapiens | 1 | ALA5137058 | cell-based format | Scientific Literature | |
6. | ALA5264642 | Binding | Protac activity at VHL/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 0.01 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%) | Homo sapiens | 18 | ALA5260842 | cell-based format | Scientific Literature | |
7. | ALA5264643 | Binding | Protac activity at VHL/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 0.1 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%) | Homo sapiens | 32 | ALA5260842 | cell-based format | Scientific Literature | |
8. | ALA5264644 | Binding | Protac activity at VHL/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 1 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%) | Homo sapiens | 33 | ALA5260842 | cell-based format | Scientific Literature | |
9. | ALA5264650 | Binding | Protac activity at VHL/AR in AR-positive human LNCaP cells assessed as reduction in protein level at 100 nM measured after 2 to 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
10. | ALA5264651 | Binding | Protac activity at VHL/AR in AR-positive human VCaP cells assessed as reduction in protein level at 100 nM measured after 2 to 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
11. | ALA5264652 | Binding | Protac activity at VHL/AR in human LNCaP cells assessed as induction of protein degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
12. | ALA5264653 | Binding | Protac activity at VHL/AR in human VCaP cells assessed as induction of protein degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
13. | ALA5264654 | Binding | Protac activity at VHL/AR in human 22Rv1 cells assessed as induction of protein degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
14. | ALA5264655 | Binding | Protac activity at VHL/AR in human VCaP cells assessed as induction of protein degradation at 10 nM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
15. | ALA5264656 | Functional | Downregulation of PSA mRNA expression in human LNCaP cells measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
16. | ALA5264657 | Functional | Downregulation of TMPRSS2 mRNA expression in human LNCaP cells measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
17. | ALA5264658 | Functional | Downregulation of FKBP5 mRNA expression in human LNCaP cells measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
18. | ALA5264659 | Functional | Downregulation of PSA mRNA expression in human VCaP cells measured after 24 hrs by regular serum based qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
19. | ALA5264660 | Functional | Downregulation of TMPRSS2 mRNA expression in human VCaP cells measured after 24 hrs by regular serum based qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature | |
20. | ALA5264661 | Functional | Downregulation of FKBP5 mRNA expression in human VCaP cells measured after 24 hrs by regular serum based qRT-PCR analysis | Homo sapiens | 1 | ALA5260842 | cell-based format | Scientific Literature |