# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4718381 | B | Inhibition of human erythrocytes mu-calpain using Pep1 as substrate incubated for 30 mins under shaking condition in presence of CaCl2 by fluorescence assay | Homo sapiens | 16 | tissue-based format | Scientific Literature | ||
2. | ALA4718382 | B | Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated for 30 mins under shaking condition by fluorescence assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
3. | ALA4718383 | B | Inhibition of cathepsin L (unknown origin) using Z-FR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated for 30 mins under shaking condition by fluorescence assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
4. | ALA4718386 | B | Inhibition of mu-calpain (unknown origin) expressed in SH-SY5Y cells assessed as reduction in p35 cleavage at 20 uM using p35 as substrate measured after 210 mins by fluorescence microplate reader assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4718389 | B | Inhibition of mu-calpain (unknown origin) expressed in HEK293T cells assessed as reduction in p35 cleavage at 5 uM using p35 as substrate measured after 210 mins by fluorescence microplate reader assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4718392 | B | Inhibition of cathepsin B in human SH-SY5Y cells using RR-AMC as substrate by fluorescence microplate reader assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA4718393 | F | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in GOx-induced PARP cleavage at 5 uM pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4718395 | F | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in GOx-induced caspase 3 cleavage pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4718396 | B | Inhibition of mu-calpain/cathepsin B in human SH-SY5Y cells assessed as reduction in GOx-induced BACE1 upregulation at 20 uM pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4718397 | F | Reduction in GOx-induced amyloid beta(1 to 42) level in human SH-SY5Y cells pretreated with GOx for 4 hrs followed by compound treatment by sandwich ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4718398 | B | Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in GOx-induced MAPK phosphorylation pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4718399 | B | Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in GOx-induced p25 phosphorylation pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4718400 | B | Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in tau phosphorylation by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4718401 | B | Competitive inhibition of human erythrocytes mu-calpain using varying level of Pep2 as substrate by Lineweaver-Burk plot analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
15. | ALA4718402 | B | Competitive inhibition of cathepsin B (unknown origin) using varying level of RR-AMC as substrate by Lineweaver-Burk plot analysis | Homo sapiens | 2 | single protein format | Scientific Literature |