# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4727484 | Binding | Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production | Mus musculus | 12 | ALA4725311 | cell-based format | Scientific Literature | |
2. | ALA4727485 | Binding | Antagonist activity at TLR9 in mouse splenocytes assessed as inhibition of CpG1585-induced IL6 production | Mus musculus | 13 | ALA4725311 | cell-based format | Scientific Literature | |
3. | ALA4727486 | Binding | Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Homo sapiens | 15 | ALA4725311 | tissue-based format | Scientific Literature | |
4. | ALA4727488 | Binding | Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Homo sapiens | 14 | ALA4725311 | cell-based format | Scientific Literature | |
5. | ALA4727489 | Binding | Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production | Homo sapiens | 13 | ALA4725311 | tissue-based format | Scientific Literature | |
6. | ALA4727492 | ADME | AUC in BALB/c mouse at 20 mg/kg, po | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
7. | ALA4727493 | ADME | Cmax in BALB/c mouse at 20 mg/kg, po | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
8. | ALA4727494 | ADME | Clearance in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
9. | ALA4727495 | ADME | Volume of distribution at steady state in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
10. | ALA4727496 | ADME | Terminal half life in BALB/c mouse at 5 mg/kg, iv | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
11. | ALA4727497 | ADME | Oral bioavailability in BALB/c mouse at 20 mg/kg | Mus musculus | 6 | ALA4725311 | organism-based format | Scientific Literature | |
12. | ALA4727498 | Binding | Antagonist activity at TLR7 ECD (unknown origin)-fused TLR9 ICD mutant (unknown origin) expressed in HEK293 cells assessed as inhibition of ssRNA40-induced NFKappaB activation | Homo sapiens | 2 | ALA4725311 | cell-based format | Scientific Literature | |
13. | ALA4727499 | Binding | Antagonist activity at TLR9 ECD (unknown origin)-fused TLR7 ICD mutant (unknown origin) expressed in HEK293 cells assessed as inhibition of R848-induced NFKappaB activation | Homo sapiens | 2 | ALA4725311 | cell-based format | Scientific Literature |