| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4714596 | B | Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4714597 | A | Cytotoxicity against Chinese Hamster MTXRII-OuaR2-4 R2 cells cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay | Cricetulus griseus | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4714598 | B | Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA4714599 | B | Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4714600 | B | Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA4714601 | F | Antiproliferative activity against human KB cells assessed as reduction in cell viability after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4714602 | F | Antiproliferative activity against human KB cells assessed as reduction in cell viability after 96 hrs in presence of folic acid by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4714603 | F | Antiproliferative activity against human IGROV1 cells assessed as reduction in cell viability after 96 hrs by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4714604 | F | Antiproliferative activity against human IGROV1 cells assessed as reduction in cell viability after 96 hrs in presence of folic acid by CellTiter-blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 10. | ALA4714605 | B | Displacement of [3H]-folic acid from human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells after 15 mins by liquid scintillation counting method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4714606 | B | Displacement of [3H]-folic acid from human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells after 15 mins by liquid scintillation counting method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4714607 | B | Inhibition of human full length N-terminal His-tagged GARFTase expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formation using 10-CHOTHF as substrate by spectrophotometric method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 13. | ALA4714608 | B | Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formation using 10-CHOTHF as substrate by spectrophotometric method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 14. | ALA4714609 | F | Antiproliferative activity against human KB cells assessed as reduction in cell viability after 96 hrs in presence of thymidine by CellTiter-blue assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 15. | ALA4714610 | F | Antiproliferative activity against human KB cells assessed as reduction in cell viability after 96 hrs in presence of adenosine by CellTiter-blue assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 16. | ALA4714611 | B | Inhibition of GARFTase in human IGROV1 assessed as increase in GAR level at 1 uM after 48 hrs by LC-MS/MS analysis | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 17. | ALA4714612 | B | Inhibition of GARFTase in human IGROV1 assessed as decrease in fGAR level at 1 uM after 48 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 18. | ALA4714613 | B | Inhibition of AICARFTase in human IGROV1 assessed as decrease in ZMP level at 1 uM after 48 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 19. | ALA4714614 | F | Inhibition of de nova purine biosynthesis in human IGROV1 assessed as decrease in IMP level at 1 uM after 48 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 20. | ALA4714615 | F | Inhibition of de nova purine biosynthesis in human IGROV1 assessed as decrease in ATP level at 1 uM after 48 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 3 | tissue-based format | Scientific Literature |
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