| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4735572 | Binding | Inhibition of recombinant human MMP2 (110 to 452 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in yeast expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 20 | ALA4732123 | assay format | Scientific Literature | |
| 2. | ALA4735573 | Binding | Inhibition of recombinant human MMP8 (99 to 269 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 20 | ALA4732123 | assay format | Scientific Literature | |
| 3. | ALA4735574 | Binding | Inhibition of recombinant human MMP9 (107 to 449 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 20 | ALA4732123 | assay format | Scientific Literature | |
| 4. | ALA4735575 | Binding | Inhibition of recombinant human MMP13 (104 to 274 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 19 | ALA4732123 | assay format | Scientific Literature | |
| 5. | ALA4735576 | Binding | Non-competitive inhibition of recombinant human MMP2 (110 to 452 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in yeast expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 6. | ALA4735577 | Binding | Non-competitive inhibition of recombinant human MMP8 (99 to 269 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 7. | ALA4735578 | Binding | Non-competitive inhibition of recombinant human MMP9 (107 to 449 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 8. | ALA4735579 | Binding | Non-competitive inhibition of recombinant human MMP13 (104 to 274 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate incubated for 15 mins followed by substrate addition and measured after 2 to 4 hrs by fluorescence based assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 9. | ALA4735580 | ADME | Cytotoxicity against mouse SN-56 cells assessed as reduction in cell viability upto 100 uM incubated for 24 hrs by MTT assay | Mus musculus | 20 | ALA4732123 | cell-based format | Scientific Literature | |
| 10. | ALA4735581 | Functional | Neuroprotective activity against H2O2-induced lipid peroxidation in mouse SN-56 cells assessed as increase in MDA level incubated for 24 hrs by lipid peroxidation MDA assay kit method | Mus musculus | 12 | ALA4732123 | cell-based format | Scientific Literature | |
| 11. | ALA4735582 | Functional | Neuroprotective activity against H2O2-induced lipid peroxidation in mouse SN-56 cells assessed as increase in MDA level at 1 to 150 uM incubated for 24 hrs by lipid peroxidation MDA assay kit method relative to control | Mus musculus | 7 | ALA4732123 | cell-based format | Scientific Literature | |
| 12. | ALA4735584 | Functional | Neuroprotective activity against H2O2-induced cytotoxicity in mouse SN-56 cells assessed as increase in cell viability at 10 to 100 uM incubated for 24 hrs by MTT assay | Mus musculus | 6 | ALA4732123 | cell-based format | Scientific Literature | |
| 13. | ALA4735586 | Binding | Non-competitive inhibition of recombinant human MMP2 (110 to 452 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in yeast expression system as substrate by fluorescence based Michaelis-Menten analysis | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 14. | ALA4735587 | Binding | Non-competitive inhibition of recombinant human MMP8 (99 to 269 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by substrate by fluorescence based Michaelis-Menten analysis | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 15. | ALA4735588 | Binding | Non-competitive inhibition of recombinant human MMP9 (107 to 449 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by substrate by fluorescence based Michaelis-Menten analysis | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 16. | ALA4735589 | Binding | Non-competitive inhibition of recombinant human MMP13 (104 to 274 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by fluorescence based Michaelis-Menten analysis assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 17. | ALA4735590 | Binding | Non-competitive inhibition of recombinant human MMP2 (110 to 452 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in yeast expression system as substrate by fluorescence based Lineweaver-Burk plot | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 18. | ALA4735591 | Binding | Non-competitive inhibition of recombinant human MMP8 (99 to 269 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by substrate by fluorescence based Lineweaver-Burk plot | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 19. | ALA4735592 | Binding | Non-competitive inhibition of recombinant human MMP9 (107 to 449 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by substrate by fluorescence based Lineweaver-Burk plot | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature | |
| 20. | ALA4735593 | Binding | Non-competitive inhibition of recombinant human MMP13 (104 to 274 residues) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 expressed in Escherichia coli expression system as substrate by fluorescence based Lineweaver-Burk plot assay | Homo sapiens | 1 | ALA4732123 | assay format | Scientific Literature |
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