| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4721243 | Binding | Inhibition of recombinant His6-Tev-LRRK2 (1326 to 2527 residues) (unknown origin) using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of ATP by TR-FRET assay | Homo sapiens | 22 | ALA4715821 | single protein format | Scientific Literature | |
| 2. | ALA4721244 | Binding | Inhibition of recombinant full-length LRRK2 (unknown origin) expressed in SH-SY5Y cells assessed as reduction in Ser935 phosphorylation after 60 mins by Alpha Screen assay | Homo sapiens | 22 | ALA4715821 | cell-based format | Scientific Literature | |
| 3. | ALA4721245 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 10 | ALA4715821 | microsome format | Scientific Literature | |
| 4. | ALA4721247 | Physicochemical | Lipophilicity, logD of compound at pH 7.4 | 12 | ALA4715821 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4721249 | ADME | Passive permeability of the compound across apical to basolateral side in MDCK2 cells transfected with Bacmam virus containing human BCRP at 3 uM after 90 mins in presence of GF120918 | Canis lupus familiaris | 10 | ALA4715821 | cell-based format | Scientific Literature | |
| 6. | ALA4721250 | Physicochemical | Solubility of the compound in FaSSIF measured after 4 hrs | 12 | ALA4715821 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4721251 | ADME | Permeability ratio across apical side to basolateral side in MDCK2 cells transfected with Bacmam virus containing human BCRP at 3 uM after 90 mins in presence or absence of GF120918 by transwell assay | Canis lupus familiaris | 10 | ALA4715821 | cell-based format | Scientific Literature |
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