| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4714773 | B | Inhibition of mouse KNa1.1 in wild type mouse CA1 pyramidal neuron assessed as decrease in number of action potential fired at 1 uM by whole cell patch clamp assay (Rvb = 213.5 +/- 15.21 No_unit) | Mus musculus | 1 | ALA4706729 | tissue-based format | Scientific Literature | |
| 2. | ALA4714774 | B | Inhibition of mouse KNa1.1 in wild type mouse CA1 pyramidal neuron assessed as decrease in number of action potential fired at 10 uM by whole cell patch clamp assay (Rvb = 216.8 +/- 10.65 No_unit) | Mus musculus | 1 | ALA4706729 | tissue-based format | Scientific Literature | |
| 3. | ALA4714775 | B | Inhibition of mouse KNa1.1 P905L mutant in Kcnt1 L/L mouse CA1 pyramidal neuron assessed as decrease in number of action potential fired at 1 uM by whole cell patch clamp assay (Rvb = 201.2 +/- 13 No_unit) | Mus musculus | 1 | ALA4706729 | tissue-based format | Scientific Literature | |
| 4. | ALA4714776 | B | Inhibition of mouse KNa1.1 P905L mutant in Kcnt1 L/L mouse CA1 pyramidal neuron assessed as decrease in number of action potential fired at 10 uM by whole cell patch clamp assay (Rvb = 284.4 +/- 31.10 No_unit) | Mus musculus | 1 | ALA4706729 | tissue-based format | Scientific Literature | |
| 5. | ALA4714777 | B | Inhibition of recombinant mouse KNa1.1 P905L mutant expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Mus musculus | 1 | ALA4706729 | cell-based format | Scientific Literature | |
| 6. | ALA4714778 | B | Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Homo sapiens | 34 | ALA4706729 | cell-based format | Scientific Literature | |
| 7. | ALA4714779 | B | Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Mus musculus | 7 | ALA4706729 | cell-based format | Scientific Literature | |
| 8. | ALA4714780 | P | Lipophilicity, log D of compound | 11 | ALA4706729 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4714781 | P | Kinetic solubility of compound | 11 | ALA4706729 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA4714782 | A | Metabolic stability in Hepatocytes (unknown origin) assessed as intrinsic clearance | Not specified | 11 | ALA4706729 | cell-based format | Scientific Literature | |
| 11. | ALA4714783 | B | Inhibition of recombinant Cynomolgus monkey KNa1.1 expressed in HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Macaca fascicularis | 1 | ALA4706729 | cell-based format | Scientific Literature | |
| 12. | ALA4714784 | B | Inhibition of recombinant rat KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Rattus norvegicus | 1 | ALA4706729 | cell-based format | Scientific Literature | |
| 13. | ALA4714785 | B | Inhibition of recombinant human KNa1.1 G288S mutant expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Homo sapiens | 1 | ALA4706729 | cell-based format | Scientific Literature | |
| 14. | ALA4714786 | B | Inhibition of recombinant human KNa1.1 F346L mutant expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay | Homo sapiens | 1 | ALA4706729 | cell-based format | Scientific Literature | |
| 15. | ALA4714787 | B | Binding affinity to TSPO (unknown origin) at 10 uM by radioligand displacement assay relative to control | Homo sapiens | 1 | ALA4706729 | single protein format | Scientific Literature | |
| 16. | ALA4714788 | B | Binding affinity to GABAA Cl- channel (unknown origin) at 10 uM by radioligand displacement assay relative to control | Homo sapiens | 1 | ALA4706729 | assay format | Scientific Literature | |
| 17. | ALA4714789 | B | Inhibition of human ERG by patch clamp analysis | Homo sapiens | 1 | ALA4706729 | assay format | Scientific Literature | |
| 18. | ALA4714790 | B | Inhibition of human Nav1.5 by patch clamp analysis | Homo sapiens | 1 | ALA4706729 | assay format | Scientific Literature | |
| 19. | ALA4714791 | B | Inhibition of Cav1.2 (unknown origin) by patch clamp analysis | Homo sapiens | 1 | ALA4706729 | assay format | Scientific Literature | |
| 20. | ALA4714792 | B | Inhibition of Iks (unknown origin) by patch clamp analysis | Homo sapiens | 1 | ALA4706729 | assay format | Scientific Literature |
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