# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4671512 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS analysis | Homo sapiens | 30 | ALA4665834 | microsome format | Scientific Literature | |
2. | ALA4671520 | P | Lipophilicity, log D of compound at pH 7.5 by HPLC analysis | 33 | ALA4665834 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4671524 | B | Selectivity ratio of IC50 for displacement of [3H]prostaglandin E2 from full-length recombinant human EP4 receptor expressed in Chem-1 cell membranes to IC50 for displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes | Homo sapiens | 36 | ALA4665834 | cell-based format | Scientific Literature | |
4. | ALA4671528 | F | Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay | Homo sapiens | 38 | ALA4665834 | cell-based format | Scientific Literature |