# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4712196 | F | Antiproliferative activity against human NCI-H3122 cells at 0.014 to 3.33 uM incubated for 3 days by WST8 assay | Homo sapiens | 4 | ALA4706631 | cell-based format | Scientific Literature | |
2. | ALA4712198 | T | Toxicity in Swiss albino mouse assessed as induction of adverse events at 50 mg/kg, ip administered as single dose and measured up to 8 hrs | Mus musculus | 2 | ALA4706631 | organism-based format | Scientific Literature | |
3. | ALA4712199 | T | Toxicity in Swiss albino mouse assessed as effect on clinical signs at 50 mg/kg, ip administered as single dose and measured up to 8 hrs | Mus musculus | 2 | ALA4706631 | organism-based format | Scientific Literature | |
4. | ALA4712200 | A | Drug level in Swiss albino mouse plasma at 50 mg/kg, ip administered as single dose and measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4706631 | organism-based format | Scientific Literature | |
5. | ALA4712201 | T | Toxicity in Swiss albino mouse assessed as drug tolerability at 50 mg/kg, ip administered as single dose and measured up to 8 hrs | Mus musculus | 2 | ALA4706631 | organism-based format | Scientific Literature | |
6. | ALA4712205 | F | Antiproliferative activity against human HT-29 cells incubated for 3 days by WST8 assay | Homo sapiens | 49 | ALA4706631 | cell-based format | Scientific Literature | |
7. | ALA4712208 | B | Inhibition of MEK1 phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
8. | ALA4712209 | B | Inhibition of MEK2 phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
9. | ALA4712210 | B | Inhibition of ERK phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4706631 | cell-based format | Scientific Literature | |
10. | ALA4712211 | B | Inhibition of MEK2 phosphorylation in human SK-MEL-28 cells at 0.0001 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
11. | ALA4712212 | B | Inhibition of ERK phosphorylation in human SK-MEL-28 cells at 0.0001 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
12. | ALA4712213 | B | Protac activity at VHL/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
13. | ALA4712214 | B | Protac activity at VHL/MEK2 in human HT-29 cells assessed as induction of MEK2 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
14. | ALA4712215 | B | Inhibition of ERK phosphorylation in human HT-29 cells pre-incubated with PD0325901 for 2 hrs followed by compound addition at 0.1 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
15. | ALA4712216 | B | Inhibition of MEK1 phosphorylation in human SK-MEL-28 cells at 0.0001 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
16. | ALA4712217 | B | Protac activity at VHL/MEK1 in human SK-MEL-28 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
17. | ALA4712218 | B | Protac activity at VHL/MEK2 in human SK-MEL-28 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
18. | ALA4712221 | B | Protac activity at VHL/MEK1 in human HT-29 cells assessed as time for induction of MEK1 degradation at 0.1 uM by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
19. | ALA4712222 | B | Protac activity at VHL/MEK2 in human HT-29 cells assessed as time for induction of MEK2 degradation at 0.1 uM by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature | |
20. | ALA4712223 | B | Inhibition of ERK phosphorylation in human HT-29 cells assessed as time for reduction in ERK phosphorylation at 0.1 uM by Western blot analysis | Homo sapiens | 2 | ALA4706631 | cell-based format | Scientific Literature |