| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4720266 | B | Agonist activity at human Nav1.4 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 2. | ALA4720267 | B | Inhibition of human Nav1.8 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 3. | ALA4720268 | B | Inhibition of human Nav1.7 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 4. | ALA4720269 | B | Inhibition of human Nav1.3 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 5. | ALA4720270 | B | Inhibition of human Nav1.5 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 6. | ALA4720271 | B | Inhibition of human Nav1.2 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 7. | ALA4720272 | B | Inhibition of human Nav1.1 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 8. | ALA4720273 | B | Inhibition of human Nav1.6 expressed in HEK293 cells incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 9. | ALA4720274 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as decrease in peak current at pulses to 0 mV by whole cell patch clamp assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 10. | ALA4720275 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as increase in current at pulses between -60 and -40 mV at 10 nM by whole cell patch clamp assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 11. | ALA4720276 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as decrease in current between potentials -10 and +50 mV at 10 nM by whole cell patch clamp assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 12. | ALA4720277 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as decrease in peak whole cell current elicited by pulse of 0 mV at 10 nM by whole cell patch clamp assay relative to control | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 13. | ALA4720278 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as V1/2 for channel activation at 10 nM by whole cell patch clamp assay (Rvb = -24.4 +/- 0.3 mV) | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 14. | ALA4720279 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as slope factor at 10 nM by whole cell patch clamp assay (Rvb = 4.8 +/- 0.3 No_unit) | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 15. | ALA4720280 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as depolarizing shift in V1/2 of NaV1.6 steady-state fast inactivation at 10 nM by whole cell patch clamp assay | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 16. | ALA4720281 | B | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as increase in channel availability at -35 mV at 10 nM by whole cell patch clamp assay relative to control | Homo sapiens | 1 | ALA4715816 | cell-based format | Scientific Literature | |
| 17. | ALA4720291 | F | Induction of nocifensive behaviors in C57BL/6 mouse assessed as induction of flinching at 10 nM, sc measured every 5 mins for 20 mins | Mus musculus | 1 | ALA4715816 | organism-based format | Scientific Literature | |
| 18. | ALA4720292 | F | Induction of nocifensive behaviors in C57BL/6 mouse assessed as induction of lifting at 10 nM, sc measured every 5 mins for 20 mins | Mus musculus | 1 | ALA4715816 | organism-based format | Scientific Literature | |
| 19. | ALA4720293 | F | Induction of nocifensive behaviors in C57BL/6 mouse assessed as induction of hind paw shaking at 10 nM, sc measured every 5 mins for 20 mins | Mus musculus | 1 | ALA4715816 | organism-based format | Scientific Literature |
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