# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4727962 | Binding | Binding affinity to human c-myc G-quadruplex DNA assessed as increase in fluorescence in presence of c-myc at 1 uM by fluorescence titration analysis | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
2. | ALA4727963 | Binding | Binding affinity to human c-myc G-quadruplex DNA in Tris Hcl buffer assessed as fluorescence lifetime of compound at 400 nm at pH 7.4 by fluorescence emission analysis (Rvb (absence of c-myc G-quadruplex DNA ) = 0.513 ns) | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
3. | ALA4727964 | Binding | Binding affinity to human c-myc G-quadruplex DNA in Tris Hcl buffer assessed as fluorescence lifetime of compound at 400 nm at pH 7.4 by Independent-site model | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
4. | ALA4727965 | Binding | Binding affinity to human c-myc G-quadruplex DNA uM by circular dichroism spectroscopy | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
5. | ALA4727966 | Binding | Effect on topology of human c-myc G-quadruplex DNA assessed as change in conformation at 245 nm at DNA to compound ratio of 1:1 by circular dichroism spectroscopy | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
6. | ALA4727967 | Binding | Effect on topology of human c-myc G-quadruplex DNA assessed as change in conformation at 265 nm at DNA to compound ratio of 5:1 by circular dichroism spectroscopy | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
7. | ALA4727968 | Binding | Induction of stabilization of human c-myc G-quadruplex assessed inhibition of Taq polymerase mediated DNA polymerization at high concentration upto 20 uM by PCR-stop assay | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
8. | ALA4727969 | ADME | Cytotoxicity against human HCCC9810 cells assessed as reduction in cell viability incubated for 72 hr by CCK8 assay | Homo sapiens | 1 | ALA4725333 | cell-based format | Scientific Literature | |
9. | ALA4727970 | ADME | Cytotoxicity against human RBE cells assessed as reduction in cell viability incubated for 72 hr by CCK8 assay | Homo sapiens | 1 | ALA4725333 | cell-based format | Scientific Literature | |
10. | ALA4727971 | ADME | Cytotoxicity against human 293T cells assessed as reduction in cell viability incubated for 72 hr by CCK8 assay | Homo sapiens | 1 | ALA4725333 | cell-based format | Scientific Literature | |
11. | ALA4727972 | Binding | Competitive binding affinity to human c-myc G-quadruplex DNA assessed as increase in fluorescence in presence of ssDNA and dsDNA at 1 uM by fluorescence titration analysis | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
12. | ALA4727973 | Binding | Binding affinity to human c-myc G-quadruplex DNA assessed as increase in fluorescence in presence of BSA/HSA at 1 uM by fluorescence titration analysis | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
13. | ALA4727974 | Binding | Binding affinity to human c-myc G-quadruplex DNA in Tris Hcl buffer assessed as increase in fluorescence intensity at 545 nm at 0 to 8 uM measured at pH 7.4 by fluorescence emission analysis | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
14. | ALA4727975 | Binding | Inhibition of hemin binding to human c-myc G4 quadruplex DNA by measuring peroxidase activity within 30 at 415 nm by G4/hemin peroxidase inhibition assay | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
15. | ALA4727976 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTGA GGG T GGG TA GGG T GGG TAAA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
16. | ALA4727977 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTG AATGGG TGGGT AGGGT GGGT AAA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
17. | ALA4727978 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTG AGGG TAAGGGT AGGGT GGGT AAA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
18. | ALA4727979 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTG AGGG TGGGT AATGGGT GGGT AAA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
19. | ALA4727980 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTG AGGG TGGGT AGGGT ATGGGT AAA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature | |
20. | ALA4727981 | Binding | Binding affinity to human c-myc G-quadruplex DNA with TTG AGGG TGGGT AGGGT GGGT AAATA flanking loops assessed as relative fluorescence intensity at 1 uM measured at pH 7.4 by fluorescent titration | Homo sapiens | 1 | ALA4725333 | nucleic acid format | Scientific Literature |