| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4715191 | F | Antagonist activity in CXCR2 (unknown origin) expressed in human HEK293 cells co-expressing Galpha16 assessed as reduction in calcium immobilization pretreated with Fluo-4AM for 45 mins followed by compound addition and measured after 10 mins by Fluo-4AM dye based fluorescence assay | Homo sapiens | 26 | ALA4706753 | cell-based format | Scientific Literature | |
| 2. | ALA4715192 | F | Antagonist activity in CXCR1 (unknown origin) expressed in human HEK293 cells co-expressing Galpha16 assessed as reduction in calcium immobilization pretreated with Fluo-4AM for 45 mins followed by compound addition and measured after 10 mins by Fluo-4AM dye based fluorescence assay | Homo sapiens | 25 | ALA4706753 | cell-based format | Scientific Literature | |
| 3. | ALA4715193 | B | Selectivity index, ratio of IC50 for CXCR1 (unknown origin) expressed in human HEK293 cells to IC50 for CXCR2 (unknown origin) expressed in human HEK293 cells | Homo sapiens | 23 | ALA4706753 | cell-based format | Scientific Literature | |
| 4. | ALA4715194 | U | Stability in simulated intestinal fluid at 1 ug/ml measured for 45 mins by LC-MS/MS analysis | 2 | ALA4706753 | assay format | Scientific Literature | ||
| 5. | ALA4715195 | U | Stability in simulated gastric fluid at 1 ug/ml measured for 45 mins by LC-MS/MS analysis | 2 | ALA4706753 | assay format | Scientific Literature | ||
| 6. | ALA4715196 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 100 ug/ml measured at 1.5 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA4706753 | microsome format | Scientific Literature | |
| 7. | ALA4715197 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 100 ug/ml measured at 1.5 hrs by LC-MS analysis | Mus musculus | 1 | ALA4706753 | microsome format | Scientific Literature | |
| 8. | ALA4715198 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 100 ug/ml measured at 1.5 hrs by LC-MS analysis | Homo sapiens | 1 | ALA4706753 | microsome format | Scientific Literature | |
| 9. | ALA4715199 | A | Metabolic stability in rat plasma assessed as compound remaining at 100 ug/ml measured at 1.5 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA4706753 | cell-free format | Scientific Literature | |
| 10. | ALA4715200 | A | Metabolic stability in human plasma assessed as compound remaining at 100 ug/ml measured at 1.5 hrs by LC-MS analysis | Homo sapiens | 1 | ALA4706753 | cell-free format | Scientific Literature | |
| 11. | ALA4715201 | B | Inhibition of human ERG | Homo sapiens | 1 | ALA4706753 | single protein format | Scientific Literature | |
| 12. | ALA4715202 | A | Elimination rate constant in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 13. | ALA4715203 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 14. | ALA4715204 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 15. | ALA4715205 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 16. | ALA4715206 | A | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 17. | ALA4715207 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 18. | ALA4715208 | A | MRT in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 19. | ALA4715209 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature | |
| 20. | ALA4715210 | A | Elimination rate constant in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4706753 | organism-based format | Scientific Literature |
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