# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4731655 | Binding | Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by ADP-Glo assay | Homo sapiens | 64 | ALA4725475 | single protein format | Scientific Literature | |
2. | ALA4731656 | Binding | Selectivity index, ratio of inhibition for PI3Kalpha (unknown origin) to inhibition for PI3K p120 gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by ADP-Glo assay | Homo sapiens | 54 | ALA4725475 | assay format | Scientific Literature | |
3. | ALA4731657 | Binding | Selectivity index, ratio of inhibition for PI3Kdelta (unknown origin) to inhibition for PI3K p120 gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by ADP-Glo assay | Homo sapiens | 54 | ALA4725475 | assay format | Scientific Literature | |
4. | ALA4731658 | Binding | Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins measured after 120 mins by by alphalisa assay | Homo sapiens | 54 | ALA4725475 | cell-based format | Scientific Literature | |
5. | ALA4731664 | ADME | Intrinsic clearance in cryopreserved human hepatocytes assessed as per million cells at 0.5 uM by LC-MS/MS analysis | Homo sapiens | 10 | ALA4725475 | cell-based format | Scientific Literature | |
6. | ALA4731665 | ADME | Intrinsic clearance in rat hepatocytes assessed as per million cells | Rattus norvegicus | 10 | ALA4725475 | cell-based format | Scientific Literature | |
7. | ALA4731666 | ADME | Clearance in Sprague-Dawley rat at 0.25 mg/kg, iv measured upto 8 hrs by LC/MS/MS analysis | Rattus norvegicus | 10 | ALA4725475 | organism-based format | Scientific Literature |