# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4650107 | Binding | Thermal Shift Assay. Domain start/stop: M626-G740 | Homo sapiens | 1,014 | ALA4649998 | single protein format | EUbOPEN Chemogenomic Library | |
2. | ALA4714171 | Binding | Protac activity at CRBN/GSPT1 in human NB-4 cells assessed as induction of GSPT1 degradation at 0.001 to 1 uM incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
3. | ALA4714184 | Binding | Protac activity at CRBN/GSPT1 in human KG-1 cells assessed as GSPT1 degradation at 1 uM incubated for 4 hrs in presence of proteasome inhibitor bortezomib by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
4. | ALA4714185 | Binding | Protac activity at CRBN/GSPT1 in human KG-1 cells assessed as GSPT1 degradation at 1 uM incubated for 4 hrs in presence of neddylation inhibitor MLN4924 by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
5. | ALA4714186 | Binding | Protac activity at CRBN/GSPT1 in human KG-1 cells assessed as GSPT1 degradation by measuring accumulation of ATF4 at 200 uM incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
6. | ALA4714187 | Binding | Protac activity at CRBN/GSPT1 in human KG-1 cells assessed as GSPT1 degradation by measuring accumulation of ATF3 at 200 uM incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
7. | ALA4714188 | Binding | Protac activity at CRBN/GSPT1 in human KG-1 cells assessed as GSPT1 degradation by measuring accumulation of CHOP at 200 uM incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
8. | ALA4714189 | Binding | Protac activity at CRBN/GSPT1 in human DF15 cells assessed as GSPT1 degradation incubated for 4 hrs by hunter detection reagent based luminescence assay | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
9. | ALA4714190 | Binding | Protac activity at CRBN/GSPT1 in human DF15 cells assessed as maximum GSPT1 degradation incubated for 4 hrs by hunter detection reagent based luminescence assay relative to control | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
10. | ALA4714191 | Binding | Protac activity at CRBN/GSPT1 in human DF-15 cells assessed as maximum GSPT1 degradation incubated for 20 hrs by hunter detection reagent based luminescence assay relative to control | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
11. | ALA4714192 | Binding | Protac activity at CRBN/IKZF1 (unknown origin) assessed as IKZF1 degradation | Homo sapiens | 1 | ALA4706692 | protein complex format | Scientific Literature | |
12. | ALA4714193 | Binding | Protac activity at CRBN/IKZF3 (unknown origin) assessed as IKZF3 degradation | Homo sapiens | 1 | ALA4706692 | protein format | Scientific Literature | |
13. | ALA4714194 | Binding | Protac activity at CRBN/GSPT1 in human DF-15 cells assessed as GSPT1 degradation at 0.2 to 3 uM incubated for 4 to 6 hrs by Incell-hunter detection reagent based luminescence assay relative to control | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
14. | ALA4714195 | Functional | Antitumor activity against human HL-60 cells in xenografted model assessed as reduction in CD33+/CD45+ in bone marrow at 5 mg/kg, BID administered for 5 consecutive days relative to control | Homo sapiens | 1 | ALA4706692 | organism-based format | Scientific Literature | |
15. | ALA4714196 | Functional | Antitumor activity against human HL-60 cells in xenografted model assessed as reduction in CD33+/CD45+ in bone marrow at 2.5 mg/kg, BID administered for 10 consecutive days relative to control | Homo sapiens | 1 | ALA4706692 | organism-based format | Scientific Literature | |
16. | ALA4714197 | Binding | Protac activity at CRBN/GSPT1 in CD3+ T cells derived from patients assessed as reduction of GSPT1 levels in peripheral blood blast administered intravenously for 5 days by flow cytometry analysis | Homo sapiens | 1 | ALA4706692 | cell-based format | Scientific Literature | |
17. | ALA4714198 | ADME | Clearance in CD1 mouse at 2 mg/kg, iv administered as bolus dose | Mus musculus | 1 | ALA4706692 | organism-based format | Scientific Literature | |
18. | ALA4714199 | ADME | Clearance in CD-IGS rat at 2 mg/kg, iv administered as bolus dose | Rattus norvegicus | 1 | ALA4706692 | organism-based format | Scientific Literature | |
19. | ALA4714200 | ADME | Clearance in cynomolgus monkey at 1 mg/kg, iv administered as bolus dose | Macaca fascicularis | 1 | ALA4706692 | organism-based format | Scientific Literature | |
20. | ALA4714201 | ADME | Volume of distribution at steady state in CD1 mouse at 2 mg/kg, iv administered as bolus dose | Mus musculus | 1 | ALA4706692 | organism-based format | Scientific Literature |