# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4668672 | A | Cytotoxicity against mouse J774.A1 cells assessed as cell viability at 10 to 20 uM after 24 hrs by MTT assay | Mus musculus | 18 | cell-based format | Scientific Literature | ||
2. | ALA4668674 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and nigerecin-induced IL-1beta production at 20 uM pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then nigericin addition for 45 mins by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
3. | ALA4668675 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and nigerecin-induced IL-1beta production pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then nigericin addition for 45 mins by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
4. | ALA4668677 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and nigericin-induced cleaved IL-1beta production at 20 uM pre-stimulated with LPS for 5 hrs before compound addition with ATP for 45 mins by Western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
5. | ALA4668678 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production at 20 uM pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then ATP addition for 45 mins by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
6. | ALA4668679 | B | Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and MSU-induced IL-1beta production at 20 uM pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then MSU addition for 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature |