| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4701415 | Binding | Inhibition of His-tagged human CDK9/cyclin T1 expressed in insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins followed by ATP and substrate addition and measured after 25 mins by TR-FRET assay | Homo sapiens | 7 | ALA4699469 | cell-based format | Scientific Literature | |
| 2. | ALA4701459 | Binding | Inhibition of His-tagged human CDK2 (M1 to L298 residue)/cyclin E1 (M1 to A395 residue) expressed in sf9 insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins followed by ATP and substrate addition and measured after 25 mins by TR-FRET assay | Homo sapiens | 3 | ALA4699469 | cell-based format | Scientific Literature | |
| 3. | ALA4701460 | Functional | Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by Cell Titre-Glo luminescent assay | Homo sapiens | 3 | ALA4699469 | cell-based format | Scientific Literature | |
| 4. | ALA4701461 | ADME | Half life in Han-Wistar rat hepatocytes at 1 uM and measured after 2 to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4699469 | cell-based format | Scientific Literature | |
| 5. | ALA4701462 | ADME | Maximum oral bioavailability in Han-Wistar rat hepatocytes based liver model at 1 uM measured after 2 to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4699469 | organism-based format | Scientific Literature | |
| 6. | ALA4701463 | Binding | Selectivity ratio of IC50 for human His-tagged human CDK2 (M1 to L298 residue)/cyclin E1 (M1 to A395 residue) expressed in sf9 insect cells to IC50 for His-tagged human CDK9/cyclin T1 expressed in insect cells | Homo sapiens | 1 | ALA4699469 | cell-based format | Scientific Literature |
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