# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4714848 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 80 mins by ADP-Glo reagent based assay | Homo sapiens | 6 | ALA4706738 | assay format | Scientific Literature | |
2. | ALA5051731 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay | Homo sapiens | 67 | ALA5050852 | assay format | Patent Bioactivity Data | |
3. | ALA5224086 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 26 | ALA5223091 | cell-based format | Scientific Literature | |
4. | ALA5224090 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Mus musculus | 23 | ALA5223091 | microsome format | Scientific Literature | |
5. | ALA5224091 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Homo sapiens | 23 | ALA5223091 | microsome format | Scientific Literature | |
6. | ALA5224092 | F | Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature | |
7. | ALA5224093 | F | Antiproliferative activity against human OVCAR-3 cells by nuclear count assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature | |
8. | ALA5224118 | A | Cmax in CD-1 mouse xenografted with human OVCAR-3 cells at 100 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
9. | ALA5224119 | A | AUC (0 to 24 hrs) in CD-1 mouse xenografted with human OVCAR-3 cells at 100 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
10. | ALA5224120 | A | Plasma concentration in CD-1 mouse xenografted with human OVCAR-3 cells at 100 mg/kg, ip measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5223091 | organism-based format | Scientific Literature | |
11. | ALA5224121 | A | Unbound fraction in CD-1 mouse plasma xenografted with human OVCAR-3 cells at 100 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature |