# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4731442 | F | Induction of mitochondria membrane potential depolarization in FRDA patient-derived lymphocyte at 2.5 uM incubated for 16 hrs by JC-1 probe based flow cytometry analysis | Homo sapiens | 12 | ALA4725467 | mitochondrion format | Scientific Literature | |
2. | ALA4731443 | F | Anti-ferroptotic activity in FRDA patient-derived Lymphocyte assessed as reduction in RSL3-induced lipid peroxidation incubated for overnight followed by RSL3 stimulation and measured after 90 mins by FACS analysis | Homo sapiens | 16 | ALA4725467 | cell-based format | Scientific Literature | |
3. | ALA4731444 | F | Inhibition of erastin-induced cell death in FRDA patient-derived fibroblast assessed as depletion of cellular ATP incubated for 12 hrs followed by erastin stimulation and measured after by luciferase-linked ATPase enzymatic assay | Homo sapiens | 15 | ALA4725467 | tissue-based format | Scientific Literature | |
4. | ALA4731446 | F | Induction of ATP production in FRDA patient-derived lymphocyte at 0.1 to 2.5 uM incubated for 24 hrs by luciferase-linked ATPase enzymatic assay | Homo sapiens | 3 | ALA4725467 | tissue-based format | Scientific Literature | |
5. | ALA4731450 | A | Cytotoxicity against FRDA patient-derived lymphocyte at 2.5 uM incubated for 24 to 48 hrs by flow cytometry analysis | Homo sapiens | 8 | ALA4725467 | cell-based format | Scientific Literature |