#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4679425	F	Effect on R6/2 mouse model of HD assessed as increase in latency to fall at 100 mg/kg, po administered twice daily for 11 weeks age starting from 5 weeks of age by rotarod test	Mus musculus	1		organism-based format	Scientific Literature
2.	ALA4679426	F	Cognitive enhancing effect in R6/2 mouse model of HD assessed as increase in spontaneous alteration at 100 mg/kg, po administered twice daily for 12 weeks starting from 5 weeks of age by Y-maze test	Mus musculus	1		organism-based format	Scientific Literature
3.	ALA4679427	F	Invivo inhibition of KMO in R6/2 mouse model of HD assessed as increase in KYNA level in striatum at 100 mg/kg, po administered twice daily for 7 weeks starting from 5 weeks age	Mus musculus	1		organism-based format	Scientific Literature
4.	ALA4679428	F	Invivo inhibition of KMO in R6/2 mouse model of HD assessed as decrease in 3-HK level in striatum at 100 mg/kg, po administered twice daily for 7 weeks starting from 5 weeks age	Mus musculus	1		organism-based format	Scientific Literature
5.	ALA4679429	A	Permeability of compound at pH 7.4 by PAMPA assay		16		assay format	Scientific Literature
6.	ALA4679430	A	Ratio of drug level in brain to plasma of mouse at 10 mg/kg, po after 1 hr	Mus musculus	9		organism-based format	Scientific Literature
7.	ALA4679431	A	Drug uptake in mouse brain at 10 mg/kg, po after 1 hr	Mus musculus	9		organism-based format	Scientific Literature
8.	ALA4679432	A	Plasma concentration in mouse at 10 mg/kg, po after 1 hr	Mus musculus	9		organism-based format	Scientific Literature
9.	ALA4679434	B	Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	6		mitochondrion format	Scientific Literature
10.	ALA4679436	B	Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Mus musculus	20		mitochondrion format	Scientific Literature
11.	ALA4836402	B	Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	17		mitochondrion format	Scientific Literature
12.	ALA4836403	A	Metabolic stability in human liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Homo sapiens	17		microsome format	Scientific Literature
13.	ALA4836404	A	Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Rattus norvegicus	17		microsome format	Scientific Literature
14.	ALA4836405	P	Glutathione reactivity assessed as dansylatedGSH-compound conjugate formation in presence of human liver microsomes by fluorescence detector based HPLC analysis		17		microsome format	Scientific Literature
15.	ALA4836407	A	Plasma concentration in mouse at 10 mg/kg, po	Mus musculus	2		organism-based format	Scientific Literature
16.	ALA4836409	A	Permeability of the compound by PAMPA		1		assay format	Scientific Literature
17.	ALA4836410	P	Solubility of the compound at pH 1.2		1		small-molecule physicochemical format	Scientific Literature
18.	ALA4836411	P	Solubility of the compound at pH 7.4		1		small-molecule physicochemical format	Scientific Literature
19.	ALA4836412	A	Half life in mouse	Mus musculus	1		organism-based format	Scientific Literature
20.	ALA4836413	A	Clearance in mouse	Mus musculus	1		organism-based format	Scientific Literature