#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4679425	Functional	Effect on R6/2 mouse model of HD assessed as increase in latency to fall at 100 mg/kg, po administered twice daily for 11 weeks age starting from 5 weeks of age by rotarod test	Mus musculus	1	ALA4673377	organism-based format	Scientific Literature
2.	ALA4679426	Functional	Cognitive enhancing effect in R6/2 mouse model of HD assessed as increase in spontaneous alteration at 100 mg/kg, po administered twice daily for 12 weeks starting from 5 weeks of age by Y-maze test	Mus musculus	1	ALA4673377	organism-based format	Scientific Literature
3.	ALA4679427	Functional	Invivo inhibition of KMO in R6/2 mouse model of HD assessed as increase in KYNA level in striatum at 100 mg/kg, po administered twice daily for 7 weeks starting from 5 weeks age	Mus musculus	1	ALA4673377	organism-based format	Scientific Literature
4.	ALA4679428	Functional	Invivo inhibition of KMO in R6/2 mouse model of HD assessed as decrease in 3-HK level in striatum at 100 mg/kg, po administered twice daily for 7 weeks starting from 5 weeks age	Mus musculus	1	ALA4673377	organism-based format	Scientific Literature
5.	ALA4679429	ADME	Permeability of compound at pH 7.4 by PAMPA assay		16	ALA4673377	assay format	Scientific Literature
6.	ALA4679430	ADME	Ratio of drug level in brain to plasma of mouse at 10 mg/kg, po after 1 hr	Mus musculus	9	ALA4673377	organism-based format	Scientific Literature
7.	ALA4679431	ADME	Drug uptake in mouse brain at 10 mg/kg, po after 1 hr	Mus musculus	9	ALA4673377	organism-based format	Scientific Literature
8.	ALA4679432	ADME	Plasma concentration in mouse at 10 mg/kg, po after 1 hr	Mus musculus	9	ALA4673377	organism-based format	Scientific Literature
9.	ALA4679434	Binding	Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	6	ALA4673377	mitochondrion format	Scientific Literature
10.	ALA4679436	Binding	Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Mus musculus	20	ALA4673377	mitochondrion format	Scientific Literature
11.	ALA4836402	Binding	Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	17	ALA4834453	mitochondrion format	Scientific Literature
12.	ALA4836403	ADME	Metabolic stability in human liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Homo sapiens	17	ALA4834453	microsome format	Scientific Literature
13.	ALA4836404	ADME	Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Rattus norvegicus	17	ALA4834453	microsome format	Scientific Literature
14.	ALA4836405	Physicochemical	Glutathione reactivity assessed as dansylatedGSH-compound conjugate formation in presence of human liver microsomes by fluorescence detector based HPLC analysis		17	ALA4834453	microsome format	Scientific Literature
15.	ALA4836407	ADME	Plasma concentration in mouse at 10 mg/kg, po	Mus musculus	2	ALA4834453	organism-based format	Scientific Literature
16.	ALA4836409	ADME	Permeability of the compound by PAMPA		1	ALA4834453	assay format	Scientific Literature
17.	ALA4836410	Physicochemical	Solubility of the compound at pH 1.2		1	ALA4834453	small-molecule physicochemical format	Scientific Literature
18.	ALA4836411	Physicochemical	Solubility of the compound at pH 7.4		1	ALA4834453	small-molecule physicochemical format	Scientific Literature
19.	ALA4836412	ADME	Half life in mouse	Mus musculus	1	ALA4834453	organism-based format	Scientific Literature
20.	ALA4836413	ADME	Clearance in mouse	Mus musculus	1	ALA4834453	organism-based format	Scientific Literature