# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4718222 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain at 300 uM using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysis relative to control | Trypanosoma cruzi | 14 | ALA4715737 | single protein format | Scientific Literature | |
2. | ALA4718223 | Functional | Antiparasitic activity against Trypanosoma cruzi Y strain trypomastigotes assessed as reduction in parasite viability after 24 hrs by Neubauer chamber counting method | Trypanosoma cruzi | 19 | ALA4715737 | organism-based format | Scientific Literature | |
3. | ALA4718224 | ADME | Cytotoxicity against BALB/c mouse splenocyte incubated for 24 hrs by [3H]-thymidine incorporation based counter beta irradiation method | Mus musculus | 19 | ALA4715737 | cell-based format | Scientific Literature | |
4. | ALA4718225 | Toxicity | Selectivity index, ratio of >90% maximum non-toxic concentration for BALB/c mouse splenocyte to IC50 for Trypanosoma cruzi Y strain trypomastigotes | 19 | ALA4715737 | assay format | Scientific Literature | ||
5. | ALA4718228 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysis | Trypanosoma cruzi | 18 | ALA4715737 | single protein format | Scientific Literature |