# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4670705 | Binding | Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measured after 20 mins by fluorescence based assay | Homo sapiens | 89 | ALA4665801 | single protein format | Scientific Literature | |
2. | ALA4670706 | Binding | Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based assay | Homo sapiens | 89 | ALA4665801 | cell-based format | Scientific Literature | |
3. | ALA4670707 | Functional | Cytotoxicity against human A673 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 89 | ALA4665801 | cell-based format | Scientific Literature | |
4. | ALA4670708 | Binding | Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based assay | Homo sapiens | 89 | ALA4665801 | cell-based format | Scientific Literature | |
5. | ALA4670709 | Functional | Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 89 | ALA4665801 | cell-based format | Scientific Literature | |
6. | ALA4670710 | Binding | Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTA | Homo sapiens | 86 | ALA4665801 | cell-based format | Scientific Literature | |
7. | ALA4670714 | Binding | Inhibition of recombinant human LDHB using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measured after 20 mins by fluorescence based assay | Homo sapiens | 88 | ALA4665801 | single protein format | Scientific Literature | |
8. | ALA4670715 | Binding | Inhibition of porcine heart MDH using malic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5 mins by resazurin based fluorescence based assay | Sus scrofa | 88 | ALA4665801 | assay format | Scientific Literature | |
9. | ALA4670716 | Binding | Selectivity ratio of IC50 for inhibition of porcine heart MDH to IC50 for inhibition of recombinant human LDHA | 88 | ALA4665801 | assay format | Scientific Literature | ||
10. | ALA4670717 | Binding | Selectivity ratio of IC50 for inhibition of porcine heart MDH to IC50 for inhibition of recombinant human LDHB | 88 | ALA4665801 | assay format | Scientific Literature |