# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4703347 | Binding | Inhibition of N-terminal 6x-His tagged FGFR4 catalytic domain (445-753 residues) (unknown origin) using IYGEFKKK substrate and [gamma-32P]-ATP incubated for 30 mins by scintillation counting based paper disk assay | Homo sapiens | 3 | ALA4699555 | single protein format | Scientific Literature | |
2. | ALA4703348 | Binding | Inhibition of N-terminal 6x-His tagged FGFR4 C552A mutant (unknown origin) using IYGEFKKK substrate and [gamma-32P]-ATP incubated for 30 mins by scintillation counting based paper disk assay | Homo sapiens | 2 | ALA4699555 | single protein format | Scientific Literature | |
3. | ALA4703349 | Binding | Inhibition of FGFR1 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
4. | ALA4703350 | Binding | Inhibition of FGFR2 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
5. | ALA4703351 | Binding | Inhibition of FGFR3 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
6. | ALA4703352 | Binding | Inhibition of FGFR4 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
7. | ALA4703353 | Binding | Inhibition of MAPKAPK2 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
8. | ALA4703354 | Binding | Inhibition of MAPKAPK3 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
9. | ALA4703355 | Binding | Inhibition of p70S6K2 (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
10. | ALA4703356 | Binding | Inhibition of TTK (unknown origin) at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
11. | ALA4703357 | Binding | Inhibition of human PI3Kalpha at 100 nM | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
12. | ALA4703358 | Binding | Inhibition of N-terminal 6x-His tagged FGFR4 catalytic domain (445-753 residues) (unknown origin) at 100 nM using IYGEFKKK substrate and [gamma-32P]-ATP incubated for 30 mins by scintillation counting based paper disk assay | Homo sapiens | 1 | ALA4699555 | single protein format | Scientific Literature | |
13. | ALA4703368 | Functional | Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by CCK8 assay | Homo sapiens | 3 | ALA4699555 | cell-based format | Scientific Literature | |
14. | ALA4703369 | Functional | Antiproliferative activity against human Hep3B cells incubated for 72 hrs by CCK8 assay | Homo sapiens | 3 | ALA4699555 | cell-based format | Scientific Literature | |
15. | ALA4703370 | Binding | Inhibition of FGFR4 in human Huh-7 cells assessed as reduction in MEK phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4699555 | cell-based format | Scientific Literature | |
16. | ALA4703371 | Binding | Inhibition of FGFR4 in human Huh-7 cells assessed as reduction in MAPK phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4699555 | cell-based format | Scientific Literature | |
17. | ALA4703372 | Binding | Inhibition of FGFR4 in human Huh-7 cells assessed as reduction in AKT phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4699555 | cell-based format | Scientific Literature | |
18. | ALA4703373 | ADME | Half life in mouse at 10 mg/kg, ip | Mus musculus | 1 | ALA4699555 | organism-based format | Scientific Literature | |
19. | ALA4703375 | Functional | Antitumor activity against human Huh-7 cells xenografted in BALB/c mouse assessed as induction of tumor regression 20 mg/kg, ip BID for 32 days | Homo sapiens | 1 | ALA4699555 | organism-based format | Scientific Literature | |
20. | ALA4703376 | Toxicity | Toxicity in BALB/c mouse xenografted with human Huh-7 cells assessed as induction of weight loss at 20 mg/kg, ip BID for 32 days | Mus musculus | 1 | ALA4699555 | organism-based format | Scientific Literature |