| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4712205 | F | Antiproliferative activity against human HT-29 cells incubated for 3 days by WST8 assay | Homo sapiens | 49 | cell-based format | Scientific Literature | ||
| 2. | ALA4712208 | B | Inhibition of MEK1 phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4712209 | B | Inhibition of MEK2 phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4712210 | B | Inhibition of ERK phosphorylation in human HT-29 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4712219 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA4712220 | B | Protac activity at CRBN/MEK2 in human HT-29 cells assessed as induction of MEK1 degradation at 0.3 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4712224 | B | Inhibition of ERK phosphorylation in human HT-29 cells assessed as time for maximum reduction in ERK phosphorylation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4712228 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as time for induction of MEK1 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4712229 | B | Protac activity at CRBN/MEK2 in human HT-29 cells assessed as time for induction of MEK2 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4712230 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as time for maximum induction of MEK1 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4712231 | B | Protac activity at CRBN/MEK2 in human HT-29 cells assessed as time for maximum induction of MEK2 degradation at 0.3 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4712239 | B | Protac activity at CRBN/MEK1 in human HT-29 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4712240 | B | Protac activity at CRBN/MEK2 in human HT-29 cells assessed as induction of MEK2 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4712241 | B | Protac activity at CRBN/MEK1 in human SK-MEL-28 cells assessed as induction of MEK1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4712242 | B | Protac activity at CRBN/MEK2 in human SK-MEL-28 cells assessed as induction of MEK2 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4712243 | B | Protac activity at CRBN/MEK1/2 in human HT-29 cells assessed as induction of MEK1/2 degradation pre-incubated with MEK1/2 inhibitor PD0325901 for 2 hrs followed by compound addition at 0.3 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4712246 | B | Protac activity at CRBN/MEK1/2 in human HT-29 cells assessed as induction of MEK1/2 degradation pre-incubated with proteasome inhibitor MG-132 for 2 hrs followed by compound addition at 0.3 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4712247 | B | Protac activity at CRBN/MEK1/2 in human HT-29 cells assessed as induction of MEK1/2 degradation pre-incubated with neddylation inhibitor MLN4924 for 2 hrs followed by compound addition at 0.3 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4712250 | B | Protac activity at CRBN/MEK1/2 in human HT-29 cells assessed as induction of MEK1/2 degradation pre-incubated with CRBN ligand pomalidomide for 2 hrs followed by compound addition at 0.3 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4712251 | B | Inhibition of MEK1/2 phosphorylation in human HT-29 cells pre-incubated with PD0325901 for 2 hrs followed by compound addition at 0.3 uM and further incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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