| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4670430 | A | Covalent inhibition of MMP19 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 2. | ALA4670431 | A | Covalent inhibition of MMP14 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 3. | ALA4670432 | A | Covalent inhibition of MMP13 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 4. | ALA4670433 | A | Covalent inhibition of MMP12 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 5. | ALA4670434 | A | Covalent inhibition of MMP9 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 6. | ALA4670435 | A | Covalent inhibition of MMP8 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 7. | ALA4670436 | A | Covalent inhibition of MMP7 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 8. | ALA4670437 | A | Covalent inhibition of MMP3 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 9. | ALA4670438 | A | Covalent inhibition of MMP2 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 10. | ALA4670439 | A | Covalent inhibition of MMP1 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4665791 | single protein format | Scientific Literature | |
| 11. | ALA4670440 | A | Cytotoxicity against human iPSC-derived neurons assessed as decrease in SNAP25 signal | Homo sapiens | 7 | ALA4665791 | tissue-based format | Scientific Literature | |
| 12. | ALA4670441 | A | Cytotoxicity against human iPSC-derived neurons assessed as effect on cell-rounding | Homo sapiens | 7 | ALA4665791 | tissue-based format | Scientific Literature | |
| 13. | ALA4670442 | A | Cytotoxicity against HEK293 cells assessed inhibition of cell proliferation after 24 hrs by MTT assay | Homo sapiens | 1 | ALA4665791 | cell-based format | Scientific Literature | |
| 14. | ALA4670444 | B | Inhibition of Clostridium botulinum BoNT/A intoxicated in hiPSC-derived neurons assessed as reduction in SNAP-25 cleavage using SNAP-25 as substrate treated 30 mins post toxin addition and measured 7 hrs post toxin addition by Western blot analysis | Clostridium botulinum | 6 | ALA4665791 | cell-based format | Scientific Literature | |
| 15. | ALA4670454 | B | Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) assessed as ratio of Kinact/Ki using SNAPtide flp6 as substrate preincubated for 0.5 to 30 mins followed by substrate addition by fluorescence assay | Clostridium botulinum | 3 | ALA4665791 | assay format | Scientific Literature | |
| 16. | ALA4670455 | B | Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) assessed as inactivation rate constant using SNAPtide flp6 as substrate preincubated for 0.5 to 30 mins followed by substrate addition by fluorescence assay | Clostridium botulinum | 3 | ALA4665791 | assay format | Scientific Literature | |
| 17. | ALA4670456 | B | Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincubated for 0.5 to 30 mins followed by substrate addition by fluorescence assay | Clostridium botulinum | 3 | ALA4665791 | assay format | Scientific Literature | |
| 18. | ALA4670457 | B | Inhibition of Clostridium botulinum BoNT/A light chain C165S mutant expressed in Escherichia coli BL21 (DE3) at 100 uM using SNAPtide flp6 as substrate incubated for 30 mins by fluorescence assay relative to control | Clostridium botulinum | 2 | ALA4665791 | assay format | Scientific Literature | |
| 19. | ALA4670458 | B | Binding affinity to Clostridium botulinum BoNT/A light chain C165S mutant expressed in Escherichia coli BL21 (DE3) assessed as compound-adduct formation by measuring change in protein mass at 100 mM measured after 4 hrs by HR-MS analysis | Clostridium botulinum | 3 | ALA4665791 | assay format | Scientific Literature | |
| 20. | ALA4670459 | B | Binding affinity to wild type Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) assessed as compound-adduct formation by measuring change in protein mass at 100 mM measured after 4 hrs by HR-MS analysis | Clostridium botulinum | 3 | ALA4665791 | assay format | Scientific Literature |
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