| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4737241 | B | Antagonist activity at human alpha4beta2 nAChR stably expressed in HEK293 cells assessed as inhibition of acethylcholine-evoked currents by whole-cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4737242 | B | Agonist activity at human alpha3beta4 nAChR stably expressed in HEK293 cells at 1 to 10 uM by whole-cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4737243 | B | Positive allosteric modulation of human alpha3beta4 nAChR stably expressed in HEK293 cells assessed as increase in acethylcholine-evoked currents at 1 to 10 uM by whole-cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4737244 | B | Displacement of [3H]Muscimol from GABAA receptor from Wistar rat brain at 10 uM incubated for 10 mins by scintillation counting method relative to control | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 5. | ALA4737245 | P | Kinetic solubility of compound in in PBS buffer at pH 7.4 by HPLC analysis | 78 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4737246 | B | Agonist activity at recombinant human nAChRalpha7 expressed in HEK293 Flip-In cells co-expressing RIC3 assessed as increase in intra cellular calcium level at 10 uM after 10 mins by fluorescence relative to control | Homo sapiens | 78 | cell-based format | Scientific Literature | ||
| 7. | ALA4737248 | B | Agonist activity at recombinant human nAChRalpha7 expressed in HEK293 Flip-In cells co-expressing RIC3 assessed as increase in intra cellular calcium level after 10 mins by fluorescence relative to control | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
| 8. | ALA4737249 | B | Positive allosteric modulation of recombinant human nAChRalpha7 expressed in HEK293 Flip-In cells co-expressing RIC3 assessed as increase in choline-induced inward current at 10 uM after 6 to 10 mins by whole-cell patch clamp method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4737250 | B | Positive allosteric modulation of recombinant human nAChRalpha7 expressed in HEK293 Flip-In cells co-expressing RIC3 assessed as increase in choline-induced inward current after 6 to 10 mins by whole-cell patch clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4737251 | A | Intrinsic clearance in human liver microsome at 1 to 2.5 uM up to 40 mins | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 11. | ALA4737252 | A | Intrinsic clearance in mouse liver microsome at 1 to 2.5 uM up to 40 mins | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 12. | ALA4737253 | A | Intrinsic clearance in rat liver microsome at 1 to 2.5 uM up to 40 mins | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 13. | ALA4737255 | A | Apparent permeability across apical to basolateral side in vinblastine-treated human Caco2 cells at 10 uM after 180 mins by HPLC or UHPLC-MS/MS analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 14. | ALA4737257 | A | Efflux ratio of apparent permeability in vinblastine-treated human Caco2 cells at 10 uM after 180 mins by HPLC or UHPLC-MS/MS analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 15. | ALA4737258 | B | Antagonist activity at human alpha4beta2 nAChR stably expressed in HEK293 cells assessed as inhibition of acethylcholine-evoked currents at 1 uM by whole-cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4737259 | B | Displacement of [3H]SR141716A from human CB1R receptor expressed in rat Chem-1 cells at 10 uM incubated for 60 mins by scintillation counting method relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4737260 | B | Displacement of [3H]Methyltrienolone from human AR receptor expressed in human LNCaP cells at 10 uM incubated for 20 hrs by scintillation counting method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4737261 | B | Displacement of [3H]GR-65630 from human 5-HT3 receptor expressed in HEK293 cells at 10 uM incubated for 60 mins by scintillation counting method relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4737262 | A | AUC (0 to 5 hrs) in Wistar rat plasma at 3 mg/kg, iv up to 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4737263 | A | AUC (0 to 5 hrs) in Wistar rat plasma at 3 mg/kg, po up to 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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