# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4709012 | A | Drug absorption of the compound incubated for 8 hrs by PAMPA-TGI assay | 14 | assay format | Scientific Literature | |||
2. | ALA4709013 | A | Permeability of the compound incubated for 8 hrs by PAMPA-TGI assay | 14 | assay format | Scientific Literature | |||
3. | ALA4709014 | B | Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
4. | ALA4709015 | F | Vasorelaxant activity in OVA-sensitized guinea pig-derived trachea assessed as decrease in CCh-induced tracheal tonic contraction in absence of functional epithelium treated with compound after contraction stabilised | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
5. | ALA4709016 | B | Inhibition of human recombinant PDE4A1A using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay relative to control | Homo sapiens | 4 | assay format | Scientific Literature | ||
6. | ALA4709017 | F | Vasorelaxant activity in OVA-sensitized guinea pig-derived trachea assessed as decrease in CCh-induced tracheal tonic contraction in presence of functional epithelium treated with compound after contraction stabilised | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
7. | ALA4709018 | F | Vasorelaxant activity in non-sensitized guinea pig-derived trachea assessed as decrease in CCh-induced tracheal tonic contraction in absence of functional epithelium treated with compound after contraction stabilised | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
8. | ALA4709019 | F | Vasorelaxant activity in non-sensitized guinea pig-derived trachea assessed as decrease in CCh-induced tracheal tonic contraction in presence of functional epithelium | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
9. | ALA4709020 | F | Antiinflammatory activity against A/J mouse assessed as decrease in LPS-induced airway hyperreactivity at 25 umol/kg, po treated via gavage for 1 hr before LPS stimulation measured after 24 hrs by whole body plethysmography relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
10. | ALA4709021 | F | Antiinflammatory activity against A/J mouse assessed as decrease in LPS-induced airway hyperreactivity at 6.25 umol/kg, po treated via gavage for 1 hr before LPS stimulation measured after 24 hrs by whole body plethysmography relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
11. | ALA4709023 | F | Antiinflammatory activity against A/J mouse assessed as decrease in LPS-induced TNFalpha production in lungs at 25 umol/kg, po treated via gavage for 1 hr before LPS stimulation and measured after 24 hrs by ELISA relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
12. | ALA4709024 | F | Antiinflammatory activity against A/J mouse assessed as decrease in LPS-induced TNFalpha production in lungs at 6.25 umol/kg, po treated via gavage for 1 hr before LPS stimulation and measured after 24 hrs by ELISA relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
13. | ALA4709026 | P | Chemical stability of the compound in phosphate buffer at pH 2.0 measured upto 120 mins by HPLC-DAD analysis | 23 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA4709027 | P | Chemical stability of the compound in phosphate buffer at pH 7.4 measured upto 120 mins by HPLC-DAD analysis | 23 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4709028 | B | Inhibition of human recombinant PDE4A1A using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
16. | ALA4709030 | B | Inhibition of human recombinant PDE4C using FAM-cAMP as substrate at 10 uM measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
17. | ALA4709031 | B | Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
18. | ALA4709033 | B | Inhibition of human recombinant PDE4A1A using FAM-cAMP as substrate at 10 uM measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
19. | ALA4709034 | B | Inhibition of human recombinant PDE4B1 using FAM-cAMP as substrate at 10 uM measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
20. | ALA4709035 | B | Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate at 10 uM measured after 1 hr by IMAP TR-FRET assay | Homo sapiens | 24 | single protein format | Scientific Literature |