# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4710047 | F | Antiproliferative activity against human A431 cells expressing wild type EGFR assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
2. | ALA4710048 | F | Antiproliferative activity against human HCC827 cells expressing EGFR del19 mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
3. | ALA4710049 | F | Antiproliferative activity against human H1975 cells expressing EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
4. | ALA4710050 | F | Antiproliferative activity against human HepG2 cells expressing VEGFR2 assessed as cell growth inhibition measured after 72 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
5. | ALA4710052 | B | Protac activity at VHL/EGFR L858R/T790M mutant in human H1975 cells assessed as induction of degradation of EGFR at 333 nM incubated for 48 hrs measured after compound wash-out for 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4710054 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation at 33 nM incubated for 24 hrs measured following drug wash-out for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4710055 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation at 33 nM incubated for 24 hrs measured following drug wash-out for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4710056 | F | Induction of apoptosis in human HCC827 cells assessed as apoptotic cells at 10 nM measured after 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4710057 | F | Induction of apoptosis in human HCC827 cells assessed as apoptotic cells at 100 nM measured after 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4710058 | F | Induction of apoptosis in human NCI-H1975 cells at 333 to 1000 nM measured after 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4710059 | F | Induction of cell cycle arrest in human HCC827 cells assessed as accumulation at G1 phase at 10 to 100 nM measured after 48 hrs by propidium iodide staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4710060 | F | Induction of cell cycle arrest in human NCI-H1975 cells assessed as accumulation at G1 phase measured at 333 to 1000 nM measured after 48 hrs by propidium iodide staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4710061 | F | Inhibition of colony formation in human HCC827 cells at 1 nM incubated for 15 days by crystal violet staining based analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4710062 | F | Inhibition of colony formation in human NCI-H1975 cells at 100 nM incubated for 15 days by crystal violet staining based analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4710063 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation at 33 nM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4710064 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation at 333 nM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4710067 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation at 33 nM by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4710069 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as maximal induction of EGFR degradation at 33 nM measured after 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4710071 | B | Protac activity at VHL/EGFR del19 mutant in human HCC827 cells assessed as induction of EGFR degradation measured after 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4710074 | B | Protac activity at VHL/EGFR L858R/T790M mutant in human H1975 cells assessed as induction of degradation of EGFR incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |